Please use this identifier to cite or link to this item: http://www.repositorio.ufop.br/handle/123456789/11088
Title: Polymorphic and quantum chemistry characterization of candesartan cilexetil : importance for the correct drug classification according to Biopharmaceutics Classification System.
Authors: Campos, Débora Priscila de
Barcellos, Neila Marcia Silva
Lima, Renata Rodrigues
Savedra, Ranylson Marcello Leal
Savedra, Melissa Fabíola Siqueira
Yoshida, Maria Irene
Mussel, Wagner da Nova
Souza, Jacqueline de
Keywords: Equilibrium solubility
Issue Date: 2018
Citation: CAMPOS, D. P. de et al. Polymorphic and quantum chemistry characterization of candesartan cilexetil : importance for the correct drug classification according to Biopharmaceutics Classification System. AAPS PharmSciTech, v. 19, n. 7, p. 3019–3028, out. 2018. Disponível em: <https://link.springer.com/content/pdf/10.1208%2Fs12249-018-1129-6.pdf>. Acesso em: 25 fev. 2019.
Abstract: The recommended method for the biopharmaceutical evaluation of drug solubility is the shake flask; however, there are discrepancies reported about the solubility of certain compounds measured with this method, one of them is candesartan cilexetil. The present work aimed to elucidate the solubility of candesartan cilexetil by associating others assays such as stability determination, polymorphic characterization and in silico calculations of intrinsic solubility, ionized species, and electronic structures using quantum chemistry descriptors (frontier molecular orbitals and Fukui functions). For the complete biopharmaceutical classification, we also reviewed the permeability data available. The polymorphic form used was previously identified as the form I of candesartan cilexetil. The solubility was evaluated in biorelevant media in the pH range of 1.2–6.8 at 37.0°C according to the stability previously assessed. The solubility of candesartan cilexetil is pH dependent and the dose/solubility ratios obtained demonstrated the low solubility of the prodrug. The in silico calculations supported the found results and evidenced the main groups involved in the solvation, benzimidazole, and tetrazol-biphenyl. The human absolute bioavailability reported demonstrates that candesartan cilexetil has low permeability and when associated with the low solubility allows to classify it as class 4 of the Biopharmaceutics Classification System.
URI: http://www.repositorio.ufop.br/handle/123456789/11088
metadata.dc.identifier.uri2: https://link.springer.com/article/10.1208%2Fs12249-018-1129-6
ISSN: 1530-9932
Appears in Collections:DEFAR - Artigos publicados em periódicos

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