Please use this identifier to cite or link to this item: http://www.repositorio.ufop.br/handle/123456789/11080
Title: Phthalocyanine photosensitizer in polyethylene glycol-block-poly(lactide-co-benzyl glycidyl ether) nanocarriers : probing the contribution of aromatic donor-acceptor interactions in polymeric nanospheres.
Authors: Lana, Gwenaelle Elza Nathalie Pound
Garcia, Giani Martins
Trindade, Izabel Cristina
Oliveira, Patricia Capelari de
Pontífice, Thaís Godinho
Vilela, José Mário Carneiro
Andrade, Margareth Spangler
Nottelet, Benjamin
Postacchini, Bruna Bueno
Mosqueira, Vanessa Carla Furtado
Keywords: Drug nanocarrier
Biodegradable polymer
Amphiphilic block copolym
Field flow fractionation
Issue Date: 2019
Citation: LANA, G. N. E. P. et al. Phthalocyanine photosensitizer in polyethylene glycol-block-poly(lactide-co-benzyl glycidyl ether) nanocarriers : probing the contribution of aromatic donor-acceptor interactions in polymeric nanospheres. Materials Science and Engineering: C, v. 94, p. 220-233, jan. 2019. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0928493118307690>. Acesso em: 7 mar. 2019.
Abstract: For best photosensitizer activity phthalocyanine dyes used in photodynamic therapy should be molecularly dispersed. Polyethylene glycol-block-polylactide derivatives presenting benzyl side-groups were synthesized to encapsulate a highly lipophilic phthalocyanine dye (AlClPc) and evaluate the effect of π-π interactions on the nanocarrier colloidal stability and dye dispersion. Copolymers with 0, 1, 2 and 6 mol% of benzyl glycidyl ether (BGE) were obtained via polyethylene glycol initiated ring-opening copolymerization of D,L-lactide with BGE. The block copolymers formed stable, monodisperse nanospheres with low in vitro cytotoxicity. AlClPc loading increased the nanosphere size and affected their colloidal stability. The photo-physical properties of the encapsulated dye, studied in batch and after separation by field flow fractionation, demonstrated the superiority of plain PEG-PLA over BGE-containing copolymers in maintaining the dye in its monomeric (non-aggregated) form in aqueous suspension. High dye encapsulation and sustained dye release suggest that these nanocarriers are good candidates for photodynamic therapy.
URI: http://www.repositorio.ufop.br/handle/123456789/11080
metadata.dc.identifier.uri2: https://www.sciencedirect.com/science/article/pii/S0928493118307690
ISSN: 0928-4931
Appears in Collections:DEFAR - Artigos publicados em periódicos

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