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Title: Evaluation of the activity of Tontelea micrantha extracts against Bacteria, Candida and Mayaro virus.
Authors: Nizer, Waleska Stephanie da Cruz
Ferraz, Ariane Coelho
Lima, William Gustavo de
Moraes, Thaís de Fátima Silva
Ferreira, Fernanda Lopes
Ferreira, Jaqueline Maria Siqueira
Magalhães, Cíntia Lopes de Brito
Duarte, Lucienir Pains
Vieira Filho, Sidney Augusto
Magalhães, José Carlos de
Keywords: Antimicrobial activity
Leaf extracts
Branch extracts
Issue Date: 2018
Citation: NIZER, W. S. da C. et al. Evaluation of the activity of Tontelea micrantha extracts against Bacteria, Candida and Mayaro virus. Journal of Pharmaceutical Negative Results, v. 9, n. 1, p. 21-26, 2018. Disponível em: <;year=2018;volume=9;issue=1;spage=21;epage=26;aulast=Cruz;type=0>. Acesso em: 22 fev. 2019.
Abstract: Objectives: This work aimed to evaluate the antibacterial, antifungal, and anti-Mayaro virus(MAYV) activity of leaf and branch extracts from Tontelea micrantha. Materials and Methods: T. micrantha extracts were prepared through the partition of the leaf and branch samples in different solvents. Then, the antibacterial and antifungal activity was assessed against bacterial pathogens and Candida sp. by the determination of the minimum inhibitory concentration (MIC) by the broth microdilution method. The activity against anti-MAYV was evaluated through the quantification of the extract concentration that promoted the protection of 50% of the cells after the viral infection. Results: The extracts of T. micrantha were inactive (MIC >500 µg/mL) against Gram-positive, Gram-negative and Candida species at the highest concentration tested (500 µg/mL). Anti-MAYV activity was also not detected, with SI <10, ranging from 1.2 to 3.6. Conclusion: Although it is used in traditional medicine, Leaf and branch extracts from T. micrantha did not present antimicrobial activity, which could be caused by the antagonistic effect of the compounds present in the extract.
ISSN: 22297723
metadata.dc.rights.license: This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. Fonte: o próprio artigo.
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