Please use this identifier to cite or link to this item: http://www.repositorio.ufop.br/handle/123456789/1036
Title: Differential impact of metacyclic and blood trypomastigotes on parasitological, serological and phenotypic features triggered during acute Trypanosoma cruzi infection in dogs.
Authors: Carneiro, Cláudia Martins
Martins Filho, Olindo Assis
Reis, Alexandre Barbosa
Veloso, Vanja Maria
Araújo, Flávio Marcos Gomes de
Bahia, Maria Terezinha
Lana, Marta de
Coelho, George Luiz Lins Machado
Gazzinelli, Giovanni
Oliveira, Rodrigo Corrêa de
Tafuri, Wagner Luiz
Keywords: Dog
Blood (BT) and metacycling (MT) trypomastigotes
Trypanosoma cruzi
Flow cytometry
Issue Date: 2007
Citation: CARNEIRO, C. M. et al. Differential impact of metacyclic and blood trypomastigotes on parasitological, serological and phenotypic features triggered during acute Trypanosoma cruzi infection in dogs. Acta Tropica, v. 101, n. 2, p. 120-129, fev. 2007. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0001706X07000046>. Acesso em: 10 jul. 2012.
Abstract: Differential impact of metacyclic and blood trypomastigotes on parasitological, serological and phenotypic features triggered during acute Trypanosoma cruzi infection in dogs A detailed follow-up investigation of the major parasitological, serological and phenotypic features in dogs experimentally infected with metacyclic (MT) and blood (BT) trypomastigotes of Trypanosoma cruzi strain Berenice-78, typifying vectorial and transfusional transmission of human Chagas disease, has been conducted. Although there were no changes with respect to the window of patent-parasitaemia, significant differences between MT- and BT-infected dogs in both the prepatent period (days 23 and 19, respectively) and the day of maximum parasitaemia (days 26 and 22, respectively) were recorded. A progressive enhancement in the level of T. cruzi -specific antibodies accompanied infection by both MT and BT forms, although higher IgG titres developed on days 14 and 21 following infection with MT forms. Higher Thy-1 + /CD21 + and lower CD4 + /CD8 + cell ratios, occasioned by increased levels of Thy-1 + and CD8 + T-cells and reduced frequencies of CD4 + T-cells and CD21 + B-lymphocytes, were observed in both MT- and BT-infected animals. The reduced frequency of CD14 + leukocytes was revealed as the most relevant phenotypic feature intrinsic to T. cruzi infection independent of inoculum source. BT-specific phenotypic features included an early reduction
URI: http://www.repositorio.ufop.br/handle/123456789/1036
ISSN: 0001706X
metadata.dc.rights.license: O periódico Acta Tropica concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3281990354506.
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