DSpace Communidade:http://www.repositorio.ufop.br/jspui/handle/123456789/85072024-03-29T14:01:08Z2024-03-29T14:01:08ZEarly treatment with pegylated interferon lambda for Covid-19.Reis, GilmarSavassi, Leonardo Cançado MonteiroGlenn, J. S.http://www.repositorio.ufop.br/jspui/handle/123456789/180372024-01-24T20:37:28Z2023-01-01T00:00:00ZTítulo: Early treatment with pegylated interferon lambda for Covid-19.
Autor(es): Reis, Gilmar; Savassi, Leonardo Cançado Monteiro; Glenn, J. S.
Resumo: BACKGROUND
The efficacy of a single dose of pegylated interferon lambda in preventing clinical
events among outpatients with acute symptomatic coronavirus disease 2019 (Covid-19) is unclear.
METHODS
We conducted a randomized, controlled, adaptive platform trial involving predominantly vaccinated adults with severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) infection in Brazil and Canada. Outpatients who presented with an
acute clinical condition consistent with Covid-19 within 7 days after the onset of
symptoms received either pegylated interferon lambda (single subcutaneous injection, 180 μg) or placebo (single injection or oral). The primary composite outcome
was hospitalization (or transfer to a tertiary hospital) or an emergency department
visit (observation for >6 hours) due to Covid-19 within 28 days after randomization.
RESULTS
A total of 933 patients were assigned to receive pegylated interferon lambda (2
were subsequently excluded owing to protocol deviations) and 1018 were assigned
to receive placebo. Overall, 83% of the patients had been vaccinated, and during
the trial, multiple SARS-CoV-2 variants had emerged. A total of 25 of 931 patients
(2.7%) in the interferon group had a primary-outcome event, as compared with 57
of 1018 (5.6%) in the placebo group, a difference of 51% (relative risk, 0.49; 95%
Bayesian credible interval, 0.30 to 0.76; posterior probability of superiority to placebo, >99.9%). Results were generally consistent in analyses of secondary outcomes, including time to hospitalization for Covid-19 (hazard ratio, 0.57; 95%
Bayesian credible interval, 0.33 to 0.95) and Covid-19–related hospitalization or
death (hazard ratio, 0.59; 95% Bayesian credible interval, 0.35 to 0.97). The effects
were consistent across dominant variants and independent of vaccination status.
Among patients with a high viral load at baseline, those who received pegylated
interferon lambda had lower viral loads by day 7 than those who received placebo.
The incidence of adverse events was similar in the two groups.
CONCLUSIONS
Among predominantly vaccinated outpatients with Covid-19, the incidence of hospitalization or an emergency department visit (observation for >6 hours) was significantly lower among those who received a single dose of pegylated interferon
lambda than among those who received placebo.2023-01-01T00:00:00ZDepression in Brazilian farmers : prevalence and associated factors.Petarli, Glenda BlaserCattafesta, MonicaViana, Maria Carmen MoldesBezerra, Olívia Maria de Paula AlvesZandonade, ElianaSalaroli, Luciane Brescianihttp://www.repositorio.ufop.br/jspui/handle/123456789/177982023-11-17T17:29:29Z2022-01-01T00:00:00ZTítulo: Depression in Brazilian farmers : prevalence and associated factors.
Autor(es): Petarli, Glenda Blaser; Cattafesta, Monica; Viana, Maria Carmen Moldes; Bezerra, Olívia Maria de Paula Alves; Zandonade, Eliana; Salaroli, Luciane Bresciani
Resumo: Background: The unique characteristics of rural areas and agricultural work can contribute to the genesis of diseases, including mental disorders such as depression.
Aims: To estimate the prevalence of and factors associated with depression symptoms in Brazilian farmers.
Methods: A cross-sectional epidemiological study involving 784 farmers of the state of Espırito Santo/Brazil was carried out. Depression was identified using the Mini-International Neuropsychiatric
Interview. Hierarchical logistic regression was used to assess the associated factors.
Results: The prevalence of depression symptoms among farmers was 16.8% (n 1⁄4 132). Of those experiencing symptoms, 6.1% (n 1⁄4 48) we’re currently experiencing a depressive episode, and 10.7% (n 1⁄4 84)
a recurrent depressive episodes. The associated factors were: female gender (OR 1.63; 95% CI
1.04–2.54), not owning the land (OR 1.79; 95% CI 1.11–2.89), professional dissatisfaction (OR 1.99; 95%
CI 1.18–3.35), previous pesticide poisoning (OR 2.87; 95% CI 1.45–5.67), complex multimorbidity (OR
1.95; 95% CI 1.15–3.31) and occurrence of previous depressive episodes (OR 9.83; 95% CI 4.39–21.99).
Conclusions: A high prevalence of depression symptoms was identified among rural workers.
Sociodemographic, occupational, clinical, and professional dissatisfaction factors were associated with
a higher risk of depression symptoms in this population.2022-01-01T00:00:00ZCut points of the conicity index and associated factors in brazilian rural workers.Prado, Camila Bruneli doMartins, Cleodice AlvesCremonini, Ana Clara PetersenFerreira, Júlia Rabelo SantosCattafesta, MonicaSouza, Juliana Almeida deZandonade, ElianaBezerra, Olívia Maria de Paula AlvesSalaroli, Luciane Brescianihttp://www.repositorio.ufop.br/jspui/handle/123456789/177972023-11-17T17:23:59Z2022-01-01T00:00:00ZTítulo: Cut points of the conicity index and associated factors in brazilian rural workers.
Autor(es): Prado, Camila Bruneli do; Martins, Cleodice Alves; Cremonini, Ana Clara Petersen; Ferreira, Júlia Rabelo Santos; Cattafesta, Monica; Souza, Juliana Almeida de; Zandonade, Eliana; Bezerra, Olívia Maria de Paula Alves; Salaroli, Luciane Bresciani
Resumo: Background: Metabolic syndrome is associated with cardiovascular complications.
Therefore, this study aims to establish cut points for the conicity index based on the components
of metabolic syndrome and to associate it with characteristic sociodemographic, food consumption
and occupational factors in Brazilian rural workers; (2) Methods: A cross-sectional study carried
out with farmers. The receiver operating characteristic curve was calculated and the cut-off points
for the conicity index were identified by the area under the curve, sensitivity and specificity. The
variables included in the binary logistic regression analysis were selected by considering p < 0.20 in the
bivariate test; (3) Results: The cut points were similar in females according to both criteria, resulting
in a single cut-off of 1.269. In males, the cut points showed differences, resulting in 1.272 according to
the NCEP-ATP III and 1.252 according to the IDF. We have shown that younger people, those who
work more than 40 h a week and the lowest contribution of culinary ingredients are associated with
increased odds of abdominal obesity, while the consumption of the products they sell or produce
decreases these chances; (4) Conclusions: The conicity index showed high discriminatory power for
the identification of abdominal obesity in rural workers. Therefore, there is a need to improve eating
habits and promote healthier eating environments for individuals, respecting traditional food culture,
mainly to contain the advance of MS in rural areas.2022-01-01T00:00:00ZPrevalência de uso de medicamentos em população rural brasileira.Mendes, Samila Breder EmerichPetarli, Glenda BlaserCattafesta, MonicaZandonade, ElianaBezerra, Olívia Maria de Paula AlvesMill, José GeraldoSalaroli, Luciane Brescianihttp://www.repositorio.ufop.br/jspui/handle/123456789/177962023-11-17T17:19:13Z2022-01-01T00:00:00ZTítulo: Prevalência de uso de medicamentos em população rural brasileira.
Autor(es): Mendes, Samila Breder Emerich; Petarli, Glenda Blaser; Cattafesta, Monica; Zandonade, Eliana; Bezerra, Olívia Maria de Paula Alves; Mill, José Geraldo; Salaroli, Luciane Bresciani
Resumo: Introdução: Apesar da vulnerabilidade social existente na população rural brasileira, o uso de medicamentos
entre agricultores é um tema ainda pouco estudado no país. Objetivo: Analisar o uso de medicamentos e
sua associação com características sociodemográficas, laborais, comportamentais e autoavaliação do estado
de saúde em agricultores. Método: Estudo epidemiológico transversal com 790 agricultores de 18 a 59 anos,
de ambos os sexos, do município de Santa Maria de Jetibá. Os medicamentos foram agrupados segundo o
Sistema de Classificação Anatômico-Terapêutico-Químico (ATC) nos níveis 1 e 2. Foram realizadas análise
descritiva (frequências absolutas e relativas) e associações entre as variáveis e o uso de medicamentos pelo
teste de qui-quadrado. As variáveis que se mostraram associadas com o desfecho com nível de significância
de 5% no teste de qui-quadrado foram testadas por regressão logística binária. Resultados: A prevalência
de uso de medicamentos foi de 44,2%, sendo menor no sexo masculino (30,3%) do que no feminino
(59,4%). Após a análise ajustada, o uso de medicamentos esteve associado ao sexo feminino, à faixa etária
de 40 anos ou mais e à pior autoavaliação do estado de saúde. A prevalência de polifarmácia foi de 6,6%.
Os medicamentos mais utilizados foram os anti-hipertensivos (19,3%). Conclusão: O estudo evidenciou a
importância de se avaliar populações rurais a fim de subsidiar políticas e recursos em saúde pública.2022-01-01T00:00:00Z