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dc.contributor.authorCustódio, Carlos Henrique Xavier-
dc.contributor.authorMiranda, José Rodolfo Rubini-
dc.contributor.authorYamaguchi, Juliana-
dc.contributor.authorSilveira, Kátia Daniela da-
dc.contributor.authorTeixeira, Mauro Martins-
dc.contributor.authorChianca Júnior, Deoclécio Alves-
dc.contributor.authorSilva, Ana Cristina Simões e-
dc.contributor.authorSantos, Robson Augusto Souza dos-
dc.contributor.authorCamargo, Antônio Carlos Martins de-
dc.contributor.authorIanzer, Danielle Alves-
dc.identifier.citationXAVIER, C. H. et al. Bj-PRO-5a and Bj-PRO 10c found at c-type natriuretic peptide precursor of bothrops jararaca change renal function of hypertensive rats. International Journal of Peptide Research And Therapeutics, v. 25, p. 1-5, 2017. Disponível em: <>. Acesso em: 15 set. 2017.pt_BR
dc.identifier.issn1573-3904 -
dc.description.abstractProline-rich oligopeptides from Bothrops jararaca (Bj-PROs) produce potent and long-lasting antihypertensive effect through mechanisms that go beyond ACE inhibition. In this study we evaluated the renal function parameters of spontaneously hypertensive rats (SHR) injected with Bj-PRO-5a and -10c (0.47, 71 or 710 nmol/ kg) found in the CNP-precursor of the snake. At 71 and 710 nmol/kg, Bj-PROs increased urinary flow rate (18.1– 43.5%). At 71 nmol/kg, Bj-PRO 5a and 10c elevated sodium excretion (68.1 and 40.9%, respectively) and Bj- PRO-5a also increased urinary sodium/creatinine ratio (56.5%). At 0.47 nmol/kg, Bj-PROs did not change renal function. All doses of Bj-PROs reduced blood pressure (Δ = −13 to −24mmHg). We conclude that Bj-PROs reduce blood pressure and improve renal functipt_BR
dc.subjectBlood pressurept_BR
dc.subjectHeart ratept_BR
dc.subjectProlinerich oligopeptidespt_BR
dc.subjectRenal functionpt_BR
dc.titleBj-PRO-5a and Bj-PRO 10c found at c-type natriuretic peptide precursor of bothrops jararaca change renal function of hypertensive rats.pt_BR
dc.typeArtigo publicado em periodicopt_BR
Appears in Collections:DECBI - Artigos publicados em periódicos

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