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Title: Lycopene pretreatment improves hepatotoxicity induced by acetaminophen in C57BL/6 mice.
Authors: Bandeira, Ana Carla Balthar
Silva, Rafaella Cecília da
Rossoni Júnior, Joamyr Victor
Figueiredo, Vivian Paulino
Silva, André Talvani Pedrosa da
Cangussú, Silvia Dantas
Bezerra, Frank Silva
Costa, Daniela Caldeira
Keywords: Redox imbalance
Issue Date: 2017
Citation: BANDEIRA, A. C. B. et al. Lycopene pretreatment improves hepatotoxicity induced by acetaminophen in C57BL/6 mice. Bioorganic & Medicinal Chemistry, v. 25, p. 1057-1065, 2017. Disponível em: <>. Acesso em: 15 set. 2017.
Abstract: Acetaminophen (APAP) is an antipyretic and analgesic drug that, in high doses, leads to severe liver injury and potentially death. Oxidative stress is an important event in APAP overdose. Researchers are looking for natural antioxidants with the potential to mitigate the harmful effects of reactive oxygen species in different models. Lycopene has been widely studied for its antioxidant properties. The aim of this study was to evaluate the antioxidant potential of lycopene pretreatment in APAP-induced liver injury in C57BL/6 mice. C57BL/6 male mice were divided into the following groups: control (C); sunflower oil (CO); acetaminophen 500 mg/kg (APAP); acetaminophen 500 mg/kg + lycopene 10 mg/kg (APAP + L10), and acetaminophen 500 mg/kg + lycopene 100 mg/kg (APAP + L100). Mice were pretreated with lycopene for 14 consecutive days prior to APAP overdose. Analyses of blood serum and livers were performed. Lycopene was able to improve redox imbalance, decrease thiobarbituric acid reactive species level, and increase CAT and GSH levels. In addition, it decreased the IL-1b expression and the activity of MMP-2. This study revealed that preventive lycopene consumption in C57BL/6 mice can attenuate the effects of APAP-induced liver injury. Furthermore, by improving the redox state, and thus indicating its potential antioxidant effect, lycopene was also shown to have an influence on inflammatory events.
ISSN: 0968-0896
metadata.dc.rights.license: O periódico Bioorganic & Medicinal Chemistry concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 4210821115986.
Appears in Collections:DECBI - Artigos publicados em periódicos

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