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Título: | Insignificant level of in vitro cytotoxicity, anti‑rotavirus, antibacterial, and antifungal activities of N‑alkylmaleamic acids. |
Autor(es): | Belinelo, Valdenir José Campos, Michele Soares Tacchi Antunes, Rafael Martins Assenço, Regina Aparecida Gomes Vieira Filho, Sidney Augusto Lanna, Maria Célia da Silva Marçal, Eduardo da Costa Fonseca, Thaisa Helena Silva Gomes, Maria Aparecida Magalhães, José Carlos de |
Palavras-chave: | Antibacterial activity Antiprotozoal activity Anti‑rotavirus N‑alkyl maleamic acid |
Data do documento: | 2013 |
Referência: | BELINELO, V. J. et al. Insignificant level of in vitro cytotoxicity, anti‑rotavirus, antibacterial, and antifungal activities of N‑alkylmaleamic acids. Journal of Pharmaceutical Negative Results, v. 4, n. 1, p. 19-25, 2013. Disponível em: <http://www.pnrjournal.com/article.asp?issn=0976-9234;year=2013;volume=4;issue=1;spage=19;epage=25;aulast=Belinelo;type=0>. Acesso em: 20 jan. 2017. |
Resumo: | By reacting maleic anhydride with amines, we synthesized the derivatives N‑ethyl, N‑(2‑ethylamine), N‑piperidinyl, N‑phenyl, and N‑phenylhydrazinyl maleamic acids. The purity of these products was initially verified by melting range and the presence of only one spot observed by thin layer chromatography. The chemical structures of the obtained N‑alkyl maleamic acids were confirmed through infrared (IR) and hydrogen and carbon nuclear magnetic resonance (1 H and 13C NMR) spectrometry. Due to the already proven pharmacological activity of maleimides, maleic anhydride and its N‑alkyl maleamic acids were subjected to in vitro assays to observe antiviral (SA‑11 rotavirus), antibacterial (Escherichia coli, Staphylococcus aureus, and Bacillus cereus), antifungal (Colletotrichum musae, Fusarium solani f. sp. phaseoli, Fusarium solani f. sp. piperis Alb., and Penicillium sp.), and antiprotozoal (Trichomonas vaginalis, Giardia lamblia, and Entamoeba histolytica) effects. To study the anti‑rotavirus properties, firstly the 3‑(4,5‑dimethylthiazol‑2‑yl)‑2‑5‑diphenyltetrazolium bromide (MTT) method was used to establish the median cytotoxicity concentration (CC50) of the compounds, using MA‑104 cell line. Under the experimental conditions used, cytotoxic, anti‑rotavirus, antibacterial, and antifungal properties were not observed for these compounds. |
URI: | http://www.repositorio.ufop.br/handle/123456789/8929 |
Link para o artigo: | http://www.pnrjournal.com/article.asp?issn=0976-9234;year=2013;volume=4;issue=1;spage=19;epage=25;aulast=Belinelo;type=0 |
DOI: | https://doi.org/10.4103/0976-9234.116762 |
ISSN: | 2229-7723 |
Aparece nas coleções: | DEFAR - Artigos publicados em periódicos |
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ARTIGO_AntioxidantPropertiesIsothiocyanates.pdf Restricted Access | 795,71 kB | Adobe PDF | Visualizar/Abrir |
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