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Título: | Antileishmanial activity of compounds produced by endophytic fungi derived from medicinal plant Vernonia polyanthes and their potential as source of bioactive substances. |
Autor(es): | Nascimento, Adriana Mendes do Soares, Mateus Gonçalves Torchelsen, Fernanda Karoline Vieira da Silva Araújo, Jorge Augusto Viana de Lage, Paula Souza Duarte, Mariana Costa Andrade, Pedro Henrique Rocha de Ribeiro, Tatiana Gomes Coelho, Eduardo Antônio Ferraz Nascimento, Andréa Mendes do |
Palavras-chave: | Endophytes Bioprospection Leishmania amazonensis |
Data do documento: | 2015 |
Referência: | NASCIMENTO, A. M. do et al. Antileishmanial activity of compounds produced by endophytic fungi derived from medicinal plant Vernonia polyanthes and their potential as source of bioactive substances. World Journal of Microbiology & Biotechnology, v. 31, p. 1793-1800, 2015. Disponível em: <https://link.springer.com/article/10.1007%2Fs11274-015-1932-0>. Acesso em: 05 ago. 2017. |
Resumo: | The purpose of this work was to evaluate the antileishmanial activity of endophytic fungi isolated from leaves of Vernonia polyanthes plant and their prospective use in the discovery of bioactive compounds. Sixteen endophytes were isolated by using potato dextrose agar medium and submitted to cultivation in rice medium. The fungal cultures were extracted with ethanol and used as crude extracts for testing their antileishmanial activity. The most active ethanol extract was obtained from P2-F3 strain, which was identified as Cochliobolus sativus by ITS rRNA gene sequence data. Followed by a bioassay-guided fractionation, the cochlioquinone A, isocochlioquinone A and anhydrocochlioquinone A compounds were isolated from the crude extracts and demonstrated to inhibit the parasites. From the present work, it is possible to conclude that endophytic fungi derived from medicinal plant V. polyanthes may be considered promising source for the discovery of bioactive compounds. |
URI: | http://www.repositorio.ufop.br/handle/123456789/8456 |
Link para o artigo: | https://link.springer.com/article/10.1007%2Fs11274-015-1932-0 |
DOI: | https://doi.org/10.1007/s11274-015-1932-0 |
ISSN: | 1573-0972 |
Aparece nas coleções: | DEQUI - Artigos publicados em periódicos |
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ARTIGO_AntileishmanialActivityCompounds.pdf Restricted Access | 441,18 kB | Adobe PDF | Visualizar/Abrir |
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