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Title: 2,2’,4-Trihydroxybenzophenone : crystal structure, and anti-inflammatory and antioxidant activities.
Authors: Doriguetto, Antônio Carlos
Martins, Felipe Terra
Ellena, Javier Alcides
Salloum, Rogério
Santos, Marcelo Henrique dos
Moreira, Maria Eliza de Castro
Silva, Jose Mauricio Schneedorf Ferreira da
Nagem, Tanus Jorge
Issue Date: 2007
Citation: DORIGUETTO, A. C. et al. 2,2’,4-Trihydroxybenzophenone: crystal structure, and anti-inflammatory and antioxidant activities. Chemistry & Biodiversity, v. 4, p. 488-499, 2007. Disponível em: <>. Acesso em: 20 mai. 2017.
Abstract: The crystal structure of C 2,2’,4-trihydroxybenzophenoneD (¼(2,4-dihydroxyphenyl)(2-hydroxyphenyl) methanone; 1) was determined, and its molecular structure, along with intra- and intermolecular Hbonds, was analyzed. The anti-inflammatory potential of 1, evaluated by means of the rat-paw-edema assay, with carrageenan as inflammation stimulus, was found to be similar high as that of indomethacin. In contrast, benzophenone proper (2) was hardly active in this assay. Our results indicate that these antiinflammatory effects are related to the action of kinins and prostaglandins. The radical-scavenging properties of 1 towards DPPH were found to be similar as those of typical phenolics, but somewhat lower than that of ascorbic acid. The structure–activity relationship (SAR) of 1 is discussed.
ISSN: 1612-1880
Appears in Collections:DEQUI - Artigos publicados em periódicos

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