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Title: Malnutrition alters the cardiovascular responses induced by central injection of tityustoxin in Fischer rats.
Authors: Silva, Fernanda Cacilda dos Santos
Guidine, Patrícia Alves Maia
Ribeiro, Mara Fernandes
Fernandes, Luciano Gonçalves
Xavier, Carlos Henrique
Menezes, Rodrigo Cunha Alvim de
Silva, Marcelo Eustáquio
Santos, Tasso Moraes
Moraes, Márcio Flávio Dutra
Chianca Júnior, Deoclécio Alves
Keywords: Scorpion envenomation
Issue Date: 2013
Citation: SILVA, F. C. S. dos et al. Malnutrition alters the cardiovascular responses induced by central injection of tityustoxin in Fischer rats. Toxicon, v. 76, p. 343-349, 2013. Disponível em: <>. Acesso em: 19 fev. 2017.
Abstract: Scorpion envenoming and malnutrition are considered two important public health problems in Brazil, involving mainly children. Both these conditions are more common among the economically stratified lower income portion of the population, thus suggesting that these factors should be analyzed concomitantly. It is known that cardiorespiratory manifestations, as cardiac arrhythmias, arterial hypertension and hypotension, pulmonary edema and circulatory failure are the main “causa mortis” of scorpion envenomation. Additionally, there are evidences in the literature that deficiencies in dietary intake endanger the CNS and modify the cardiovascular homeostasis. Then, the objective of this work is to evaluate the protein malnourished effect on cardiovascular responses induced by tityustoxin (TsTX, an a-type toxin extracted from the Tityus serrulatus scorpion venom). Fischer rats (n ¼ 20) were injected i.c.v. with TsTX and divided in control and malnorished groups, which were, respectively, submitted to a control and a low-protein diet. Arterial pressure recordings were done until death of the animals. Although both groups presented an increased mean arterial pressure after TsTX injection, this increase was smaller and delayed in malnourished rats, when compared to control rats. In addition, heart rate increased only in rats from the control group. Finally, malnourished rats had an increase in survival time (9:9/13.5
ISSN: 0041-0101
Appears in Collections:DECBI - Artigos publicados em periódicos

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