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Título: | Anti-mycobacterium tuberculosis and cytotoxicity activities of Ruthenium(II)/ bipyridine/diphosphine/pyrimidine-2-thiolate complexes : the role of the non- coordinated N-atom. |
Autor(es): | Benedicto, Augusto Vieira Lima Correa, Rodrigo de Souza Graminha, Angelica Ellen Kuznetsov, Aleksey Evgenyevich Ellena, Javier Alcides Pavan, Fernando Rogério Leite, Clarice Queico Fujimura Batista, Alzir Azevedo |
Palavras-chave: | Ruthenium complexes Pyrimidine-2-thiolate Diphosphine ligand Cytotoxity - tuberculosis |
Data do documento: | 2016 |
Referência: | BENEDICTO, A. V. L. et al. Anti-mycobacterium tuberculosis and cytotoxicity activities of Ruthenium(II)/ bipyridine/diphosphine/pyrimidine-2-thiolate complexes: the role of the non-coordinated N-atom. Journal of the Brazilian Chemical Society, v. 27, p. 30-40, 2016. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532016000100030>. Acesso em: 26 set. 2016. |
Resumo: | The [Ru(Spym)(bipy)(P–P)]PF6, [Spym = pyrimidine-2-thiolate anion; P–P = 1,2-bis(diphenylphosphino)ethane, 1,3-bis(diphenylphosphino)propane and 1,1’-bis(diphenylphosphino)ferrocene] complexes were synthesized and characterized by spectroscopic, electrochemical and elemental analysis, and by X-ray crystallography. The minimal inhibitory concentration (MIC) of the compounds against Mycobacterium tuberculosis and the complex concentration causing 50% tumor cell growth inhibition (IC50) against breast cancer cells, MDA-MB-231, were determined. All three compounds gave promising values in both tests. It is interesting to mention that all three complexes display MICs against Mycobacterium tuberculosis showing higher activity than cycloserine, a second line drug used in the treatment of the illness. The complexes interact weakly with the DNA. |
URI: | http://www.repositorio.ufop.br/handle/123456789/7066 |
DOI: | http://dx.doi.org/10.5935/0103-5053.20150237 |
ISSN: | 1678-4790 |
Licença: | Todo o conteúdo do periódico Journal of the Brazilian Chemical Society, exceto onde identificado, está sob uma licença Creative Commons 4.0 que permite copiar, distribuir e transmitir o trabalho em qualquer suporte ou formato desde que sejam citados o autor e o licenciante. Não permite o uso para fins comerciais. Fonte: Journal of the Brazilian Chemical Society <http://www.scielo.br/scielo.php?script=sci_serial&pid=0103-5053&lng=en&nrm=iso>. Acesso em: 23 ago. 2019. |
Aparece nas coleções: | DEQUI - Artigos publicados em periódicos |
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ARTIGO_AntiMycobacteriumTuberculosis.pdf | 776,37 kB | Adobe PDF | Visualizar/Abrir |
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