Please use this identifier to cite or link to this item: http://www.repositorio.ufop.br/jspui/handle/123456789/4565
Title: Brown adipose tissue thermogenesis heats brain and body as part of the brain-coordinated ultradian basic rest-activity cycle.
Authors: Ootsuka, Youichirou
Menezes, Rodrigo Cunha Alvim de
Zaretsky, Dmitry V.
Alimoradian, A.
Hunt, J.
Stefanidis, A.
Oldfield, B. J.
Blessing, William W.
Keywords: Thermoregulation
Temperature
Sleep
Arterial blood pressure
Wavelet mathematics
Issue Date: 2009
Citation: OOTSUKA, Y. et al. Brown adipose tissue thermogenesis heats brain and body as part of the brain-coordinated ultradian basic rest-activity cycle. Physiology & Behavior, p. 129-137, 2013. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0031938413001625>. Acesso em: 08 nov. 2014.
Abstract: Brown adipose tissue (BAT), body and brain temperatures, as well as behavioral activity, arterial pressure and heart rate, increase episodically during the waking (dark) phase of the circadian cycle in rats. Phase-linking of combinations of these ultradian (<24 h) events has previously been noted, but no synthesis of their overall interrelationships has emerged. We hypothesized that they are coordinated by brain central command, and that BAT thermogenesis, itself controlled by the brain, contributes to increases in brain and body temperature. We used chronically implanted instruments to measure combinations of bat, brain and body temperatures, behavioral activity, tail artery blood flow, and arterial pressure and heart rate, in conscious freely moving Sprague–Dawley rats during the 12-h dark active period. Ambient temperature was kept constant for any particular 24-h day, varying between 22 and 27 °C on different days. Increases in BAT temperature (>0.5 °C) occurred in an irregular episodic manner every 94_43 min (mean_SD). Varying the temperature over a wider range (18–30 °C) on different days did not change the periodicity, and neither body nor brain temperature fell before BAT temperature episodic increases. These increases are thus unlikely to reflect thermoregulatory homeostasis. Episodic BAT thermogenesis still occurred in food-deprived rats. Behavioral activity, arterial pressure (18_5 mmHg every 98_49 min) and heart rate (86_31 beats/min) increased approximately 3 min before each increase in BAT temperature. Increases in BAT temperature (1.1_0.4 °C) were larger than corresponding increases in brain (0.8_0.4 °C) and body (0.6_0.3 °C) temperature and the BAT episodes commenced 2–3 min before body and brain episodes, suggesting that BAT thermogenesis warms body and brain. Hippocampal 5–8 Hz theta rhythm, indicating active engagement with the environment, increased before the behavioral and autonomic events, suggesting coordination by brain central command as part of the 1–2 h ultradian basic rest-activity cycle (BRAC) proposed by Kleitman.
URI: http://www.repositorio.ufop.br/handle/123456789/4565
metadata.dc.identifier.doi: https://doi.org/10.1016/j.physbeh.2013.05.021
ISSN: 0031-9384
metadata.dc.rights.license: O periódico Physiology & Behavior concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3547120523166.
Appears in Collections:DECBI - Artigos publicados em periódicos

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