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Campo Dublin Core | Valor | Idioma |
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dc.contributor.author | Resende, Daniela de Melo | - |
dc.contributor.author | Caetano, Bráulia Costa | - |
dc.contributor.author | Dutra, Míriam Santos | - |
dc.contributor.author | Abrantes, Christiane de Freitas | - |
dc.contributor.author | Verly, Rodrigo Moreira | - |
dc.contributor.author | Resende, Jarbas Magalhães | - |
dc.contributor.author | Veloso, Dorila Piló | - |
dc.contributor.author | Rezende, Simone Aparecida | - |
dc.contributor.author | Romero, Oscar Bruna | - |
dc.contributor.author | Fernandes, Ana Paula Salles Moura | - |
dc.contributor.author | Gazzinelli, Ricardo Tostes | - |
dc.date.accessioned | 2014-11-20T15:59:10Z | - |
dc.date.available | 2014-11-20T15:59:10Z | - |
dc.date.issued | 2008 | - |
dc.identifier.citation | RESENDE, D. de M. et al. Epitope mapping and protective immunity elicited by adenovirus expressing the Leishmania amastigote specific A2 antigen : correlation with IFN- and cytolytic activity by CD8+ T cells. Vaccine, v. 26, p. 4585-4593, 2008. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0264410X08006932>. Acesso em: 28 ago. 2014. | pt_BR |
dc.identifier.issn | 0264-410X | - |
dc.identifier.uri | http://www.repositorio.ufop.br/handle/123456789/4003 | - |
dc.description.abstract | A2was identified as an amastigote virulence factor of Leishmania (Leishmania) donovani and as a candidate antigen for vaccine development against visceral leishmaniasis. Here, predicted hydrophilic, class I and II MHC-binding synthetic peptides were used to define epitopes recognized by A2-specific antibodies, CD8+ T and CD4+ T cells, respectively. Immunization of BALB/c mice with adenovirus expressing A2 (AdA2) resulted in lowantibody response, contrasting with high levels of IFN-_ producing CD4+ T and CD8+ T cells specific for A2. Further, A2-specific CD8+ T cells from immunized mice were capable of lysing sensitized target cells in vivo. Finally, we demonstrated an association of A2-specific T cell responses and reduced parasitism in both liver and spleen from mice immunized with AdA2 and challenged with L. (L.) chagasi. | pt_BR |
dc.language.iso | en_US | pt_BR |
dc.subject | Leishmaniasis | pt_BR |
dc.subject | Recombinant vaccine | pt_BR |
dc.subject | Epitope mapping | pt_BR |
dc.title | Epitope mapping and protective immunity elicited by adenovirus expressing the Leishmania amastigote specific A2 antigen : correlation with IFN- and cytolytic activity by CD8+ T cells. | pt_BR |
dc.type | Artigo publicado em periodico | pt_BR |
dc.rights.license | O periódico Vaccine concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3460890061017. | pt_BR |
dc.identifier.doi | https://doi.org/10.1016/j.vaccine.2008.05.091 | - |
Aparece nas coleções: | DEACL - Artigos publicados em periódicos |
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ARTIGO_Epitopemappingprotective.pdf | 935,04 kB | Adobe PDF | Visualizar/Abrir |
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