Please use this identifier to cite or link to this item: http://www.repositorio.ufop.br/jspui/handle/123456789/4003
Title: Epitope mapping and protective immunity elicited by adenovirus expressing the Leishmania amastigote specific A2 antigen : correlation with IFN- and cytolytic activity by CD8+ T cells.
Authors: Resende, Daniela de Melo
Caetano, Bráulia Costa
Dutra, Míriam Santos
Abrantes, Christiane de Freitas
Verly, Rodrigo Moreira
Resende, Jarbas Magalhães
Veloso, Dorila Piló
Rezende, Simone Aparecida
Romero, Oscar Bruna
Fernandes, Ana Paula
Gazzinelli, Ricardo Tostes
Keywords: Leishmaniasis
Recombinant vaccine
Epitope mapping
Issue Date: 2008
Citation: RESENDE, D. de M. et al. Epitope mapping and protective immunity elicited by adenovirus expressing the Leishmania amastigote specific A2 antigen : correlation with IFN- and cytolytic activity by CD8+ T cells. Vaccine, v. 26, p. 4585-4593, 2008. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0264410X08006932>. Acesso em: 28 ago. 2014.
Abstract: A2was identified as an amastigote virulence factor of Leishmania (Leishmania) donovani and as a candidate antigen for vaccine development against visceral leishmaniasis. Here, predicted hydrophilic, class I and II MHC-binding synthetic peptides were used to define epitopes recognized by A2-specific antibodies, CD8+ T and CD4+ T cells, respectively. Immunization of BALB/c mice with adenovirus expressing A2 (AdA2) resulted in lowantibody response, contrasting with high levels of IFN-_ producing CD4+ T and CD8+ T cells specific for A2. Further, A2-specific CD8+ T cells from immunized mice were capable of lysing sensitized target cells in vivo. Finally, we demonstrated an association of A2-specific T cell responses and reduced parasitism in both liver and spleen from mice immunized with AdA2 and challenged with L. (L.) chagasi.
URI: http://www.repositorio.ufop.br/handle/123456789/4003
metadata.dc.identifier.doi: https://doi.org/10.1016/j.vaccine.2008.05.091
ISSN: 0264-410X
metadata.dc.rights.license: O periódico Vaccine concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3460890061017.
Appears in Collections:DEACL - Artigos publicados em periódicos

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