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Título: | Microinjection of NMDA antagonist into the NTS of conscious rats blocks the Bezold-Jarisch reflex. |
Autor(es): | Chianca Júnior, Deoclécio Alves Machado, Benedito Honório |
Palavras-chave: | Phosphonovaleric acid Sympatho-inhibition Bradycardia Cardiopulmonary receptor Amino acid receptor |
Data do documento: | 1996 |
Referência: | CHIANCA, JÚNIOR, D. A.; MACHADO, B. H. Microinjection of NMDA antagonist into the NTS of conscious rats blocks the Bezold-Jarisch reflex. Brain Research, v. 718, n. 1-2, p. 185-188, abr. 1996. Disponível em: <https://www.sciencedirect.com/science/article/pii/0006899396000108>. Acesso em: 26 nov. 2012. |
Resumo: | The purpose of the present study was to evaluate whether or not cardiovagal excitatory and sympatho-inhibitory pathways of the Bezold-Jarischreflex at the NTS level were mediated by NMDA receptors. The Bezold-Jarischreflex was activated by intravenous (i.v.) injection of serotonin in consciousrats before and after microinjection of phosphonovaleric acid (AP-5), a selective NMDAantagonist, into the NTS. The Bezold-Jarischreflex was also activated before and after methyl-atropine (i.v.) in order to evaluate if the changes in mean arterial pressure were dependent on the bradycardic response. The data showed that AP-5 into the NTS produced a dose-dependent reduction in both bradycardic and hypotensive responses to activation of the Bezold-Jarischreflex. Methyl-atropine also blocked the bradycardic and hypotensive responses to Bezold-Jarischreflex activation. The data show that in consciousrats the cardiovagal component of the Bezold-Jarischreflex plays a major role in the cardiovascular changes produced by the activation of this reflex and suggest that the neurotransmission of the cardiovagal component of the Bezold-Jarischreflex is mediated by NMDA receptors. |
URI: | http://www.repositorio.ufop.br/handle/123456789/1822 |
ISSN: | 00068993 |
Licença: | O periódico Brain Research concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3314370015968 |
Aparece nas coleções: | DECBI - Artigos publicados em periódicos |
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ARTIGO_MicroinjectionNmdaAntagonist.pdf | 603,02 kB | Adobe PDF | Visualizar/Abrir |
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