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dc.contributor.authorMachado, Benedito Honório-
dc.contributor.authorChianca Júnior, Deoclécio Alves-
dc.contributor.authorHaibara, Andréa Siqueira-
dc.contributor.authorMauad, Helde-
dc.contributor.authorColombari, Eduardo-
dc.identifier.citationMACHADO, B. H. et al. Autonomic processing of the cardiovascular reflexes in the nucleus tractus solitarii. Brazilian Journal of Medical and Biological Research, v. 30, n. 4, p. 533-543, abr. 1997. Disponível em: <>. Acesso em: 26 nov. 2012.pt_BR
dc.description.abstractThe nucleus tractus solitarii (NTS) receives afferent projections from the arterial baroreceptors, carotid chemoreceptors and cardiopulmonary receptors and as a function of this information produces autonomic adjustments in order to maintain arterial blood pressure within a narrow range of variation. The activation of each of these cardiovascular afferents produces a specific autonomic response by the excitation of neuronal projections from the NTS to the ventrolateral areas of the medulla (nucleus ambiguus, caudal and rostral ventrolateral medulla). The neurotransmitters at the NTS level as well as the excitatory amino acid (EAA) receptors involved in the processing of the autonomic responses in the NTS, although extensively studied, remain to be completely elucidated. In the present review we discuss the role of the EAA L-glutamate and its different receptor subtypes in the processing of the cardiovascular reflexes in the NTS. The data presented in this review related to the neurotransmission in the NTS are based on experimental evidence obtained in our laboratory in unanesthetized rats. The two major conclusions of the present review are that a) the excitation of the cardiovagal component by cardiovascular reflex activation (chemo- and Bezold-Jarisch reflexes) or by L-glutamate microinjection into the NTS is mediated by N-methyl-D-aspartate (NMDA) receptors, and b) the sympatho-excitatory component of the chemoreflex and the pressor response to L-glutamate microinjected into the NTS are not affected by an NMDA receptor antagonist, suggesting that the sympatho-excitatory component of these responses is mediated by non-NMDA receptors.pt_BR
dc.subjectBezold-Jarisch reflexpt_BR
dc.subjectKynureic acidpt_BR
dc.subjectExcitatory amino acid receptorspt_BR
dc.titleAutonomic processing of the cardiovascular reflexes in the nucleus tractus solitarii.pt_BR
dc.typeArtigo publicado em periodicopt_BR
dc.rights.licenseTodo o conteúdo do periódico Brazilian Journal of Medical and Biological Research, exceto onde identificado, está licenciado sob uma licença Creative Commons 4.0 que permite copiar, distribuir e transmitir o trabalho em qualquer suporte ou formato desde que sejam citados o autor e o licenciante. Fonte: Brazilian Journal of Medical and Biological Research <>. Acesso em: 20 out. 2016.-
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