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Title: Long-term e-cigarette aerosol exposure causes pulmonary emphysema in adult female and male mice.
Authors: Rodriguez Herrera, Andrea Jazel
Souza, Ana Beatriz Farias de
Castro, Thalles de Freitas
Machado Júnior, Pedro Alves
Marcano Gomez, Elena Cecilia
Menezes, Tatiana Prata
Castro, Maria Laura da Cruz
Silva, André Talvani Pedrosa da
Costa, Daniela Caldeira
Cangussú, Silvia Dantas
Bezerra, Frank Silva
Keywords: Cigarette smoke
Electronic cigarette
C57BL/6 mice
Issue Date: 2023
Citation: RODRIGUEZ HERRERA, A. J. et al. Long-term e-cigarette aerosol exposure causes pulmonary emphysema in adult female and male mice. Regulatory Toxicology and Pharmacology, v. 142, artigo 105412, ago. 2023. Disponível em: <>. Acesso em: 01 ago. 2023.
Abstract: This study aimed to evaluate long-term exposure to conventional cigarette smoke (CC) and electronic cigarette (EC) aerosol in adult male and female C57BL/6 mice. Forty-eight C57BL/6 mice were used, male (n = 24) and female (n = 24), both were divided into three groups: control, CC and EC. The CC and EC groups were exposed to cigarette smoke or electronic cigarette aerosol, respectively, 3 times a day for 60 consecutive days. Afterwards, they were maintained for 60 days without exposure to cigarettes or electronic cigarette aerosol. Both cigarettes promoted an influx of inflammatory cells to the lung in males and females. All animals exposed to CC and EC showed an increase in lipid peroxidation and protein oxidation. There was an increase of IL-6 in males and females exposed to EC. The IL-13 levels were higher in the females exposed to EC and CC. Both sexes exposed to EC and CC presented tissue damage characterized by septal destruction and increased alveolar spaces compared to control. Our results demonstrated that exposure to CC and EC induced pulmonary emphysema in both sexes, and females seem to be more susceptible to EC.
ISSN: 0273-2300
Appears in Collections:DECBI - Artigos publicados em periódicos

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