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Title: Hepatic and neurobiological effects of foetal and breastfeeding and adulthood exposure to methylmercury in wistar rats.
Authors: Silva, Helen Tais da Rosa
Panzenhagen, Alana Castro
Schmidtt, Victoria
Teixeira, Alexsander Alves
Espitia Perez, Pedro
Franco, Álvaro de Oliveira
Mingori, Moara
Ávila, José Fernando Torres
Schnorr, Carlos Eduardo
Hermann, Paolla Rissi Silva
Moraes, Diogo Pompeu
Almeida, Roberto Farina de
Moreira, José Cláudio Fonseca
Keywords: Oxidative stress
Double exposure
Issue Date: 2020
Citation: SILVA, H. T. da R. et al. Hepatic and neurobiological effects of foetal and breastfeeding and adulthood exposure to methylmercury in wistar rats. Chemosphere, v. 244, artigo 125400, 2020. Disponível em: <>. Acesso em: 11 out. 2022.
Abstract: Methylmercury (MeHg) is an organic bioaccumulated mercury derivative that strongly affects the environment and represents a public health problem primarily to riparian communities in South America. Our objective was to investigate the hepatic and neurological effects of MeHg exposure during the phases foetal and breast-feeding and adult in Wistar rats. Wistar rats (n 1⁄4 10) were divided into 3 groups. Control group received mineral oil; The simple exposure (SE) group was exposed only in adulthood (0.5 mg/kg/day); and double exposure (DE) was pre-exposed to MeHg 0.5 mg/kg/day during pregnancy and breastfeeding (±40 days) and re-exposed to MeHg for 45 days from day 100. After, we evaluated possible abnormalities. Behavioral and biochemical parameters in liver and occipital cortex (CO), markers of liver injury, redox and AKT/GSK3b/mTOR signaling pathway. Our results showed that both groups treated with MeHg presented significant alterations, such as decreased locomotion and exploration and impaired visuospatial perception. The rats exposed to MeHg showed severe liver damage and increased hepatic glycogen concentration. The MeHg groups showed significant impairment in redox balance and oxidative damage to liver macromolecules and CO. MeHg upregulated the AKT/GSK3b/mTOR pathway and the phosphorylated form of the Tau protein. In addition, we found a reduction in NeuN and GFAP immunocontent. These results represent the first approach to the hepatotoxic and neural effects of foetal and adult MeHg exposure.
ISSN: 0045-6535
Appears in Collections:DECBI - Artigos publicados em periódicos

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