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Título: | Assessment of the biological potential of diaryltriazene-derived triazene compounds. |
Autor(es): | Figueirêdo, Patricia de Maria Silva Sampaio Filho, José Costa Sodré, Alzirene de Jesus Sales Castro Júnior, José Ribamar de Gonçalves, Ingrid Santos Blasques, Rodrigo Vieira Correa, Rodrigo de Souza Lima, Benedicto Augusto Vieira Marques, Larissa dos Anjos Coutinho, Denise Fernandes Santos, Ana Paula Silva de Azevedo dos Luz, Tássio Rômulo Silva Araújo Miranda, Rita de Cassia Mendonça de Santos, Julliana Ribeiro Alves dos Doriguetto, Antônio Carlos Pividori, María Isabel Hörner, Manfredo Villis, Paulo Cesar Mendes |
Data do documento: | 2021 |
Referência: | FIGUEIRÊDO, P. de M. S. et al. Assessment of the biological potential of diaryltriazene-derived triazene compounds. Scientific Reports, v. 11, artigo 2541, 2021. Disponível em: <https://www.nature.com/articles/s41598-021-81823-2>. Acesso em: 10 jun. 2021. |
Resumo: | In the present study, novel, 1,3-diaryltriazene-derived triazene compounds were synthesized and tested. Triazenes are versatile and belong to a group of alkylating agents with interesting physicochemical properties and proven biological activities. This study describes the synthesis, molecular and crystalline structure, biological activity evaluation, and antifungal and antimicrobial potentials of 1,3-bis(X-methoxy-Y-nitrophenyl)triazenes [X= 2 and 5; Y= 4 and 5]. The antimicrobial and antifungal activities of the compounds were tested by evaluating the sensitivity of bacteria (American Type Culture Collection, ATCC) and clinical isolates to their solutions using standardized microbiological assays, cytotoxicity evaluation, and ecotoxicity tests. The antimicrobial potentials of triazenes were determined according to their minimum inhibitory concentrations (MICs); these compounds were active against gram-positive and gram-negative bacteria, with low MIC values. The most surprising result was obtained for T3 having the efective MIC of 9.937 µg/mL and antifungal activity against Candida albicans ATCC 90028, C. parapsilosis ATCC 22019, and C. tropicallis IC. To the best of our knowledge, this study is the frst to report promising activities of triazene compounds against yeast and flamentous fungi. The results showed the potential utility of triazenes as agents afecting selected resistant bacterial and fungal strains. |
URI: | http://www.repositorio.ufop.br/jspui/handle/123456789/14278 |
DOI: | https://doi.org/10.1038/s41598-021-81823-2 |
Licença: | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. Fonte: o PDF do artigo. |
Aparece nas coleções: | DEQUI - Artigos publicados em periódicos |
Arquivos associados a este item:
Arquivo | Descrição | Tamanho | Formato | |
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ARTIGO_AssessmentBiologicalPotential.pdf | 2,15 MB | Adobe PDF | Visualizar/Abrir |
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