Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorVale, Isabela Natália Pascoal Campos do-
dc.contributor.authorSaliba, Juliana Wilke-
dc.contributor.authorFonseca, Giuliana Schmidt França-
dc.contributor.authorPascoal, Vanessa Peruhype Magalhães-
dc.contributor.authorAraújo, Fernanda Fortes de-
dc.contributor.authorXavier, Marcelo Antônio Pascoal-
dc.contributor.authorCarvalho, Andréa Teixeira de-
dc.contributor.authorCampos, Fernanda Magalhães Freire-
dc.contributor.authorAndrade, Mariléia Chaves-
dc.contributor.authorLula, Jamille Fernandes-
dc.contributor.authorReis, Alexandre Barbosa-
dc.contributor.authorLemos, Elenice Moreira-
dc.contributor.authorCarvalho, Sílvio Fernando Guimarães de-
dc.contributor.authorOliveira, Edward-
dc.contributor.authorMartins Filho, Olindo Assis-
dc.identifier.citationVALE, I. N. P. C. do et al. Laboratorial algorithm for serological diagnosis of visceral leishmaniasis using rK39-ICT, DAT-LPC and FC-Simplex IgG1. Journal of Immunological Methods, v. 480, p. 112765, 2020. Disponível em: <>. Acesso em: 10 jun. 2021.pt_BR
dc.description.abstractThe performance of distinct serological tests (rK39-ICT, IFAT, DAT-LPC, FC-Simplex IgG1) was assessed and a laboratorial algorithm was proposed for accurate diagnosis of VL. DAT-LPC and FC-Simplex IgG1 showed outstanding accuracy (AUC = 0.93) to identify VL patients. The use of a sequential serological algorithm (rK39-ICT screening followed by DAT-LPC or FC-Simplex IgG1) improved the global accuracy for VL (97.2%) diagnosis. An alternative approach for diagnosis of VL has been also assessed for interchangeable use of serum/whole blood lysate samples in DAT-LPC and FC-Simplex IgG1. Our data showed an outstanding agreement for the results obtained with whole blood lysate samples as compared to serum samples (DAT-LPC =100%; FC-Simplex IgG1 = 99%). Together, these findings provide insights to improve the current overall accuracy of VL diagnosis and present innovative laboratorial tests and alternative samples from use in public health services.pt_BR
dc.titleLaboratorial algorithm for serological diagnosis of visceral leishmaniasis using rK39-ICT, DAT-LPC and FC-Simplex IgG1.pt_BR
dc.typeArtigo publicado em periodicopt_BR
Appears in Collections:DEACL - Artigos publicados em periódicos

Files in This Item:
File Description SizeFormat 
  Restricted Access
1,17 MBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.