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dc.contributor.authorRoatt, Bruno Mendes-
dc.contributor.authorCardoso, Jamille Mirelle de Oliveira-
dc.contributor.authorBrito, Rory Cristiane Fortes de-
dc.contributor.authorVital, Wendel Coura-
dc.contributor.authorSoares, Rodrigo Dian de Oliveira Aguiar-
dc.contributor.authorReis, Alexandre Barbosa-
dc.identifier.citationROATT, B. M. et al. Recent advances and new strategies on leishmaniasis treatment. Applied Microbiology and Biotechnology, v. 104, p. 8965-8977, 2020. Disponível em: <>. Acesso em: 10 jun. 2021.pt_BR
dc.description.abstractLeishmaniasis is one of the most important tropical neglected diseases according to the World Health Organization. Even after more than a century, we still have few drugs for the disease therapy and their great toxicity and side effects put in check the treatment control program around the world. Moreover, the emergence of strains resistant to conventional drugs, co-infections such as HIV/Leishmania spp., the small therapeutic arsenal (pentavalent antimonials, amphotericin B and formulations, and miltefosine), and the low investment for the discovery/development of new drugs force researchers and world health agencies to seek new strategies to combat and control this important neglected disease. In this context, the aim of this review is to summarize new advances and new strategies used on leishmaniasis therapy addressing alternative and innovative treatment paths such as physical and local/topical therapies, combination or multi-drug uses, immunomodulation, drug repurposing, and the nanotechnology-based drug delivery systems.pt_BR
dc.subjectConventional chemotherapypt_BR
dc.subjectMulti-drug therapypt_BR
dc.subjectDrug repurposingpt_BR
dc.titleRecent advances and new strategies on leishmaniasis treatment.pt_BR
dc.typeArtigo publicado em periodicopt_BR
Appears in Collections:DEACL - Artigos publicados em periódicos

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