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Título: | Physical and biological effects of paclitaxel encapsulation on disteraroylphosphatidylethanolamine-polyethyleneglycol polymeric micelles. |
Autor(es): | Oda, Caroline Mari Ramos Gasperini, Antonio Augusto Malfatti Souza, Angelo Malachias de Lana, Gwenaelle Elza Nathalie Pound Mosqueira, Vanessa Carla Furtado Fernandes, Renata Salgado Oliveira, Mônica Cristina de Barros, André Luís Branco de Leite, Elaine Amaral |
Palavras-chave: | Paclitaxel 1,2-distearoyl-sn-glycero-3-phosphoethanolamine - poly ethylene glycol Small-angle x-ray scattering analysis Câncer |
Data do documento: | 2020 |
Referência: | ODA, C. M. R. et al. Physical and biological effects of paclitaxel encapsulation on disteraroylphosphatidylethanolamine-polyethyleneglycol polymeric micelles. Colloids and Surfaces B: Biointerfaces, v. 188, p. 110760, abr. 2020. Disponível em: <https://www.sciencedirect.com/science/article/pii/S092777651930904X?via%3Dihub>. Acesso em: 10 fev. 2020. |
Resumo: | Simple size observations of 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethyleneglycol)-2000] (DSPE-mPEG2000) polymeric micelles (PM) with different compositions including or not paclitaxel (PTX) are unable to evidence changes on the nanocarrier structure. In such system a detailed characterization using highly sensitive techniques such as X-ray scattering and asymmetric flow field flow fractionation coupled to multi-angle laser light scattering and dynamic light scattering (AF4-MALS-DLS) is mandatory to observe effects that take place by the addition of PTX and/or more lipid-polymer at PM, leading to complex changes on the structure of micelles, as well as in their supramolecular organization. SAXS and AF4-MALS-DLS suggested that PM can be found in the medium separately and highly organized, forming clusters of PM in the latter case. SAXS fitted parameters showed that adding the drug does not change the average PM size since the increase in core radius is compensated by the decrease in shell radius. SAXS observations indicate that PEG conformation takes place, changing from brush to mushroom depending on the PM composition. These findings directly reflect in in vivo studies of blood clearance that showed a longer circulation time of blank PM when compared to PM containing PTX. |
URI: | http://www.repositorio.ufop.br/handle/123456789/12281 |
Link para o artigo: | https://www.sciencedirect.com/science/article/pii/S092777651930904X?via%3Dihub |
DOI: | https://doi.org/10.1016/j.colsurfb.2019.110760 |
ISSN: | 0927-7765 |
Aparece nas coleções: | DEFAR - Artigos publicados em periódicos |
Arquivos associados a este item:
Arquivo | Descrição | Tamanho | Formato | |
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ARTIGO_PhysicalBiologicalEffects.pdf Restricted Access | 2,55 MB | Adobe PDF | Visualizar/Abrir |
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