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Título: | Endothelium-dependent vasodilation induced by Hancornia speciosa in rat superior mesenteric artery. |
Autor(es): | Ferreira, Herick Campos Serra, Carla Penido Endringer, Denise Coutinho Lemos, Virgínia Soares Braga, Fernão Castro Côrtes, Steyner de França |
Palavras-chave: | Hancornia speciosa Resistance artery Vasodilation Endothelium Nitric oxide |
Data do documento: | 2007 |
Referência: | FERREIRA, H. C. et al. Endothelium-dependent vasodilation induced by Hancornia speciosa in rat superior mesenteric artery. Phytomedicine, v. 14, n. 7-8, p. 473-478, ago. 2007. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0944711306001711>. Acesso em: 30 jul. 2012. |
Resumo: | The vasodilator effect of the ethanolic extract of leaves from Hancornia speciosa Gomes (HSE) was evaluated in superior mesenteric artery rings. HSE produced a concentration-dependent vasodilation (IC50 ¼ 10.874.0 mg/mL) in arterial rings pre-contracted with phenylephrine, which was completely abolished in endothelium-denuded vessels. Endothelium-dependent vasodilation induced by HSE was strongly reduced by L-NAME (100 mM), a nitric oxide (NO) synthase inhibitor, but neither by atropine, a muscarinic receptor antagonist (1 mM), nor by indomethacin (10 mM), a cyclooxygenase inhibitor. In rings pre-contracted with 80mM KCl, the vasodilator effect of HSE was shifted to the right and was completely abolished in the presence of L-NAME (100 mM). Similar effects were obtained in mesenteric rings pre-contracted with phenylephrine in the presence of KCl 25mM alone or in addition to 100 mM L-NAME.In addition, BaCl2 (1mM) dramatically reduced the vasodilation induced by HSE. Together, these findings led usv to conclude that HSE induces an endothelium-dependent vasodilation in rat mesenteric artery, by a mechanism dependent on NO, on the activation of potassium channels and endothelium-derived hyperpolarizing factor release. Rutin, identified as a major peak in the HPLC fingerprint obtained for HSE, might contribute for the observed vasodilator effect, since it was able to induce an endothelium-dependent vasodilation in rat superior mesenteric arteries. |
URI: | http://www.repositorio.ufop.br/handle/123456789/1213 |
ISSN: | 09447113 |
Licença: | O periódico Phytomedicine concede permissão ao Repositório Institucional da UFOP para depositar este artigo. Número da Licença: 3233040896043. |
Aparece nas coleções: | DEFAR - Artigos publicados em periódicos |
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ARTIGO_EndotheliumDependentVasodilation.pdf | 395,04 kB | Adobe PDF | Visualizar/Abrir |
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