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Title: Immunogenicity of a killed Leishmania vaccine with saponin adjuvant in dogs.
Authors: Giunchetti, Rodolfo Cordeiro
Oliveira, Rodrigo Corrêa de
Martins Filho, Olindo Assis
Carvalho, Andréa Teixeira de
Roatt, Bruno Mendes
Soares, Rodrigo Dian de Oliveira Aguiar
Souza, Juliana Vitoriano de
Moreira, Nádia das Dores
Malaquias, Luiz Cosme Cotta
Castro, Luciana Lisboa Mota e
Lana, Marta de
Reis, Alexandre Barbosa
Keywords: Canine visceral leishmaniasis
Saponin adjuvant
Celland humoral immune response
Issue Date: 2007
Citation: GIUNCHETTI, R. C. et al. Immunogenicity of a killed Leishmania vaccine with saponin adjuvant in dogs. Vaccine, v. 25, n. 44, p. 7674-7686, nov. 2007. Disponível em: <>. Acesso em: 10 jul. 2012.
Abstract: Cellular and humoral immune responses of dogs to a candidate vaccine, composed of Leishmania braziliensis promastigote protein plus saponin as adjuvant, have been investigated as a pre-requisite to understanding the mechanisms of immunogenicity against canine visceral leishmaniasis (CVL). The candidate vaccine elicited strong antigenicity related to the increases of anti- Leishmania IgG isotypes, together with higher levels of lymphocytes, particularly of circulating CD8 + T-lymphocytes and Leishmania chagasi antigen-specific CD8 + T-lymphocytes. As indicated by the intense cell proliferation and increased nitric oxide production during in vitro stimulation by L. chagasisoluble antigens, the candidate vaccine elicited an immune activation status potentially compatible with effective control of the etiological agent of CVL.
ISSN: 0264410X
metadata.dc.rights.license: O periódico Vaccine concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3291410072386.
Appears in Collections:DEACL - Artigos publicados em periódicos

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