DSpace Coleção:
http://www.repositorio.ufop.br/jspui/handle/123456789/3890
2024-01-23T11:10:05ZEmotionally subjective reactivity to cervical cytology pictures is modulated by expertise.
http://www.repositorio.ufop.br/jspui/handle/123456789/17622
Título: Emotionally subjective reactivity to cervical cytology pictures is modulated by expertise.
Autor(es): Oliveira, Jacqueline Alfenas de; Souza, Miriam de Cássia; Cunha, Laila Fernandes da; Mota, Bruna Eugênia Ferreira; Rezende, Mariana Trevisan; Carneiro, Claudia Martins; Pereira, Mirtes Garcia; Mocaiber, Izabela; Souza, Gabriela Guerra Leal de
Resumo: Our aims were to create a catalog of cytological pictures and to evaluate the valence (level of pleasantness/
unpleasantness) and arousal (level of calm/excitement) of these pictures in individuals with different
occupations. The sample consisted of medical and law college students and cytopathologists. Valence and
arousal score for general pictures were not modulated by expertise in cytology. However, students judged
the cytological pictures to be lower in valence and in arousal than the cytopathologists. The cytopathologists
classified cytological pictures with lesions as lower in valence and higher in arousal than cytological pictures
without lesions.2022-01-01T00:00:00ZThe orphan G protein-coupled receptor, GPR139, is expressed in the hypothalamus and is involved in the regulation of body mass, blood glucose, and insulin.
http://www.repositorio.ufop.br/jspui/handle/123456789/17621
Título: The orphan G protein-coupled receptor, GPR139, is expressed in the hypothalamus and is involved in the regulation of body mass, blood glucose, and insulin.
Autor(es): Nogueira, Pedro Augusto Silva; Assis, Alexandre Moura; Zanesco, Ariane Maria; Bombassaro, Bruna; Ferraz, Ana Luísa Gallo; Simões, Marcela Rodrigues; Engel, Daiane Fátima; Razolli, Daniela Soares; Gaspar, Joana Margarida Navalho; Donato Junior, José; Velloso, Licio Augusto
Resumo: GPR139 is an orphan G-protein-coupled receptor that is expressed in restricted areas of the nervous system,
including the hypothalamus. In this study, we hypothesized that GPR139 could be involved in the regulation of
energy balance and metabolism. In the first part of the study, we confirmed that GPR139 is expressed in the
hypothalamus and particularly in proopiomelanocortin and agouti-related peptide neurons of the mediobasal
hypothalamus. Using a lentivirus with a short-hairpin RNA, we inhibited the expression of GPR139 bilaterally in
the mediobasal hypothalamus of mice. The intervention promoted a 40% reduction in the hypothalamic
expression of GPR139, which was accompanied by an increase in body mass, a reduction in fasting blood glucose
levels, and an increase in insulin levels. In the hypothalamus, inhibition of GPR139 was accompanied by a
reduction in the expression of orexin. As previous studies using a pharmacological antagonist of orexin showed a
beneficial impact on type 2 diabetes and glucose metabolism, we propose that the inhibition of hypothalamic
GPR139 could be acting indirectly through the orexin system to control systemic glucose and insulin. In
conclusion, this study advances the characterization of GPR139 in the hypothalamus, demonstrating its
involvement in the regulation of body mass, blood insulin, and glycemia.2023-01-01T00:00:00ZSerum biomarkers in patients with unilateral or bilateral active pulmonary tuberculosis : immunological networks and promising diagnostic applications.
http://www.repositorio.ufop.br/jspui/handle/123456789/17620
Título: Serum biomarkers in patients with unilateral or bilateral active pulmonary tuberculosis : immunological networks and promising diagnostic applications.
Autor(es): Pascoal, Vanessa Peruhype Magalhães; Araújo, Fernanda Fortes de; Papini, Tatiane Figueiredo de Morais; Wendling, Ana Paula Barbosa; Azevedo, Ana Carolina Campi; Reis, Jordana Grazziela Alves Coelho dos; Almeida, Isabela Neves de; Antonnelli, Lis Ribeiro do Valle; Amaral, Laurence Rodrigues do; Gomes, Matheus de Souza; Sousa, Joaquim Pedro Brito de; Santos, Silvana Maria Elói; Augusto, Valéria Maria; Dalcolmo, Margareth Maria Pretti; Carneiro, Cláudia Martins; Carvalho, Andréa Teixeira de; Martins Filho, Olindo Assis
Resumo: The present observational study was designed to characterize the integrative profile of serum soluble mediators
to describe the immunological networks associated with clinical findings and identify putative biomarkers for
diagnosis and prognosis of active tuberculosis. The study population comprises 163 volunteers, including 84
patients with active pulmonary tuberculosis/(TB), and 79 controls/(C). Soluble mediators were measured by
multiplexed assay. Data analysis demonstrated that the levels of CCL3, CCL5, CXCL10, IL-1β, IL-6, IFN-γ, IL-1Ra,
IL-4, IL-10, PDGF, VEGF, G-CSF, IL-7 were increased in TB as compared to C. Patients with bilateral pulmonary
involvement/(TB-BI) exhibited higher levels of CXCL8, IL-6 and TNF with distinct biomarker signatures (CCL11,
CCL2, TNF and IL-10) as compared to patients with unilateral infiltrates/(TB-UNI). Analysis of biomarker networks based in correlation power graph demonstrated small number of strong connections in TB and TB-BI. The
search for biomarkers with relevant implications to understand the pathogenetic mechanisms and useful as
complementary diagnosis tool of active TB pointed out the excellent performance of single analysis of IL-6 or
CXCL10 and the stepwise combination of IL-6 → CXCL10 (Accuracy = 84 %; 80 % and 88 %, respectively).
Together, our finding demonstrated that immunological networks of serum soluble biomarkers in TB patients
differ according to the unilateral or bilateral pulmonary involvement and may have relevant implications to
understand the pathogenetic mechanisms involved in the clinical outcome of Mtb infection.2023-01-01T00:00:00ZLong non-coding rna and chemoresistance in bladder cancer – a mini review.
http://www.repositorio.ufop.br/jspui/handle/123456789/17619
Título: Long non-coding rna and chemoresistance in bladder cancer – a mini review.
Autor(es): Lima, Ana Paula Braga; Silva, Glenda Nicioli da
Resumo: Bladder cancer is the 10th most common cancer worldwide. It is a heterogeneous disease,
comprising several tumor subtypes with differences in histology, genomic aberrations, prognosis and sensitivity to anti-cancer treatments. Although the treatment of bladder cancer is
based tumor classifications and gradings, patients have different clinical response. In recent
years, long non-coding RNAs (lncRNAs) were associated with bladder cancer chemoresistance. Thus, lncRNAs seem to be promising targets in treatment of bladder cancer. This
review highlights the recent findings concerning lncRNAs and their relevance to the chemoresistance of bladder cancer. This may provide a basis for exploiting more robust therapeutic approaches in the future.2022-01-01T00:00:00Z