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Título: Severe pediatric asthma refractory to treatment : the ongoing challenge of exacerbation.
Autor(es): Queiroz, Mônica Versiani Nunes Pinheiro de
Queiroz, Joana Versiani Chiabi de
Lasmar, Laura Maria de Lima Belizário Facury
Palavras-chave: Severe refractory asthma
Predictive factors
Children and adolescents
Data do documento: 2017
Referência: QUEIROZ, M. V. N. P. de; QUEIROZ, J. V. C. de; LASMAR, L. M. de L. B. F. Severe pediatric asthma refractory to treatment : the ongoing challenge of exacerbation. Clinical Research in Pulmonology, v. 5, p. 1043-1050, 2017. Disponível em: <>. Acesso em: 05 abr. 2018.
Resumo: The objective of this study was to review the last 16 years of literature on the clinical and functional risk factors for asthma exacerbation, as well as on biochemical parameters in severe pediatric asthma refractory to treatment (SPART). In searches of the Cochrane/Brazilian Virtual Library of Health, Latin American and Caribbean Health Sciences Literature, Medline, Brazilian Office for the Advancement of Higher Education, and PubMed databases, we employed the following search terms/strings: “severe asthma” or “refractory asthma” or “problematic asthma” or “difficult-to-treat asthma”; “exacerbation”; “risk factors” or “predictors”; and “pediatric” or “children and adolescents”. We limited our searches to articles published between 1999 and 2016. We selected 26 original or review articles on severe pediatric asthma that addressed age, recent severe exacerbations, the level of asthma control, regular followup, comorbidities, behavioral factors, viral infection, and passive smoking, biomarkers of inflammation, serum vitamin D levels, and pulmonary function. However, we found very few studies dealing with SPART. Severe asthma is a heterogeneous, dynamic disease in which the various predictors of exacerbation described assess different aspects of the disease and are complementary. Such factors should be analyzed from a multifactorial and individualized perspective, because many of them are potentially modifiable.
ISSN: 23336625
Licença: Open Access Publication by JSciMed Central is licensed under a Creative Commons Attribution 4.0 International License. Fonte: Clinical Research In Pulmonology. Disponível em: <>. Acesso em: 13 abr. 2018.
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