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Título: | Despite Leishvaccine and Leishmune ® trigger distinct immune profiles, their ability to activate phagocytes and CD8 + T-cells support their high-quality immunogenic potential against canine visceral leishmaniasis. |
Autor(es): | Araújo, Márcio Sobreira Silva Andrade, Renata Aline de Vianna, Leonardo Rocha Mayrink, Wilson Reis, Alexandre Barbosa Avelar, Renato Sathler Carvalho, Andréa Teixeira de Andrade, Mariléia Chaves Melo, Maria Norma Martins Filho, Olindo Assis |
Palavras-chave: | Canine visceral leishmaniasis Leishvaccine Leishmune Lymphocyte phenotypes |
Data do documento: | 2008 |
Referência: | ARAÚJO, M. S. S. et al. Despite Leishvaccine and Leishmune ® trigger distinct immune profiles, their ability to activate phagocytes and CD8 + T-cells support their high-quality immunogenic potential against canine visceral leishmaniasis. Vaccine, v. 26, n.18, p. 2211-2224, abr. 2008. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0264410X08002351>. Acesso em: 05 jul. 2012. |
Resumo: | Phenotypic features of peripheral blood leukocytes have been investigated as a prerequisite to characterize the protective immunity attributed to both Leishvaccine and Leishmune ® . Our results showed that either those vaccine were accompanied by distinct profiles on innate immune compartment. While Leishvaccine promoted early changes in phenotypic fea-tures of neutrophils and eosinophils with late involvement of monocytes, Leishmune ® induced early and persistent activation of neutrophils and monocytes, without changes on eosinophil activation status. Regarding the adaptive immunity, Leishvaccine sponsored a mixed profile, associated with phenotypic changes of T and B-lymphocytes. Major phenotypic changes in CD4 + T-cells with transient activation of CD8 + T-cell, besides decreased frequency of B-cell expressing |
URI: | http://www.repositorio.ufop.br/handle/123456789/986 |
ISSN: | 0264410X |
Licença: | O periódico Vaccine concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3291401473802. |
Aparece nas coleções: | DEACL - Artigos publicados em periódicos |
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ARTIGO_DespiteLeishvaccineLeishmune.pdf | 1,15 MB | Adobe PDF | Visualizar/Abrir |
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