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dc.contributor.authorGiunchetti, Rodolfo Cordeiro-
dc.contributor.authorOliveira, Rodrigo Corrêa de-
dc.contributor.authorMartins Filho, Olindo Assis-
dc.contributor.authorCarvalho, Andréa Teixeira de-
dc.contributor.authorRoatt, Bruno Mendes-
dc.contributor.authorSoares, Rodrigo Dian de Oliveira Aguiar-
dc.contributor.authorVital, Wendel Coura-
dc.contributor.authorAbreu, Raquel Trópia de-
dc.contributor.authorMalaquias, Luiz Cosme Cotta-
dc.contributor.authorGontijo, Nelder de Figueiredo-
dc.contributor.authorBrodskyn, Cláudia-
dc.contributor.authorOliveira, Camila Indiani de-
dc.contributor.authorCosta, Dirceu Joaquim-
dc.contributor.authorLana, Marta de-
dc.contributor.authorReis, Alexandre Barbosa-
dc.identifier.citationGIUNCHETTI, R. C. et al. A killed Leishmania vaccine with sand fly saliva extract and saponin adjuvant displays immunogenicity in dogs. Vaccine, v. 26, n. 5, p. 623-638, jan. 2008. Disponível em: <>. Acesso em: 05 jul. 2012.pt_BR
dc.description.abstractA vaccine against canine visceral leishmaniasis (CVL), comprising Leishmania braziliensispromastigote protein, sand fly gland extract (SGE) and saponin adjuvant, was eval-uated in dog model, in order to analyse the immunogenicity of the candidate vaccine. The vaccine candidate elicited strong antigenicity in dogs in respect of specific SGE andLeishmania humoral immune response. The major saliva proteins recognized by serum from immunized dogs exhibited molecular weights of 35 and 45 kDa, and were related to the resistance pattern against Leishmaniainfection. Immunophenotypic analysis revealed increased circulating CD21 + B-cells and CD5 + T-cells, reflected by higher counts of CD4 + and CD8 + T-cells. The observed interac-tion between potential antigen-presenting cells (evaluated as CD14 + monocytes) and lymphocyte activation status indicated a relationship between innate and adaptive immune responses. The higher frequency in L. chagasi antigen-specific CD8 + T-lymphocytes, and their positive association with intense cell proliferation, in addition to the progressively higher production of serum nitric oxide levels, showed a profile compatible with anti-CVL vaccine potential. Further studies on immunological response after challenge with L. chagasi may provide important information that will lead to a better understanding on vaccine trial and efficacy.pt_BR
dc.subjectCanine visceral leishmaniasispt_BR
dc.subjectCell and humoral immune responsept_BR
dc.subjectFlow cytometrypt_BR
dc.titleA killed Leishmania vaccine with sand fly saliva extract and saponin adjuvant displays immunogenicity in dogs.pt_BR
dc.typeArtigo publicado em periodicopt_BR
dc.rights.licenseO periódico Vaccine concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3291401392425.-
Appears in Collections:DEACL - Artigos publicados em periódicos

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