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Título: | Histopathological and immunohistochemical investigations of the hepatic compartment associated with parasitism and serum biochemical changes in canine visceral leishmaniasis. |
Autor(es): | Giunchetti, Rodolfo Cordeiro Mayrink, Wilson Carneiro, Cláudia Martins Oliveira, Rodrigo Corrêa de Martins Filho, Olindo Assis Marques, Marcos José Tafuri, Wagner Luiz Reis, Alexandre Barbosa |
Palavras-chave: | Dog Histopathology Immunohistochemistry Leishmania chagasi Liver |
Data do documento: | 2008 |
Referência: | GIUNCHETTI, R. C. et al. Histopathological and immunohistochemical investigations of the hepatic compartment associated with parasitism and serum biochemical changes in canine visceral leishmaniasis. Veterinary Science, v. 84, n. 2, p. 269-277, abr. 2008. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0034528807001245>. Acesso em: 05 jul. 2012. |
Resumo: | The immunopathological evaluation of the hepatic compartment associated with parasitism and biochemical findings are essential for understanding the genesis of hepatomegaly in anine visceral leishmaniasis (CVL). Three clinical groups of dogs naturally infected with Leishmania chagasi[i.e., asymptomatic (AD, n = 12), oligosymptomatic (OD,n = 12) and symptomatic (SD,n = 17)] were assessed and compared with a group of non-infected dogs (NID,n = 11). Intense reaction of the Kupffer cells, capsule and portal inflammation, and the presence of intralobular granulomas, were observed in the different clinical groups. Dogs in the SD group presented a higher frequency of parasitism compared with the AD group. Inflammatory alterations were more intense in the SD group and were associated with parasit-ism. Our results indicated an association between histological liver changes and the progression of biochemical alterations according to pro-gression of clinical forms of CVL, and the direct relationship between clinical symptoms and frequency of hepatic parasitism. |
URI: | http://www.repositorio.ufop.br/handle/123456789/972 |
ISSN: | 03784312 |
Licença: | O periódico Research in Veterinary Science concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3281420662301. |
Aparece nas coleções: | DEACL - Artigos publicados em periódicos |
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ARTIGO_HistopathologicalImmunohistochemicalInvestigations.pdf | 1,02 MB | Adobe PDF | Visualizar/Abrir |
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