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Título: | Bj-PRO-5a and Bj-PRO 10c found at c-type natriuretic peptide precursor of bothrops jararaca change renal function of hypertensive rats. |
Autor(es): | Custódio, Carlos Henrique Xavier Miranda, José Rodolfo Rubini Yamaguchi, Juliana Silveira, Kátia Daniela da Teixeira, Mauro Martins Chianca Júnior, Deoclécio Alves Silva, Ana Cristina Simões e Santos, Robson Augusto Souza dos Camargo, Antônio Carlos Martins de Ianzer, Danielle Alves |
Palavras-chave: | Blood pressure Heart rate Hypertension Prolinerich oligopeptides Renal function |
Data do documento: | 2017 |
Referência: | XAVIER, C. H. et al. Bj-PRO-5a and Bj-PRO 10c found at c-type natriuretic peptide precursor of bothrops jararaca change renal function of hypertensive rats. International Journal of Peptide Research And Therapeutics, v. 25, p. 1-5, 2017. Disponível em: <https://link.springer.com/article/10.1007/s10989-017-9575-7>. Acesso em: 15 set. 2017. |
Resumo: | Proline-rich oligopeptides from Bothrops jararaca (Bj-PROs) produce potent and long-lasting antihypertensive effect through mechanisms that go beyond ACE inhibition. In this study we evaluated the renal function parameters of spontaneously hypertensive rats (SHR) injected with Bj-PRO-5a and -10c (0.47, 71 or 710 nmol/ kg) found in the CNP-precursor of the snake. At 71 and 710 nmol/kg, Bj-PROs increased urinary flow rate (18.1– 43.5%). At 71 nmol/kg, Bj-PRO 5a and 10c elevated sodium excretion (68.1 and 40.9%, respectively) and Bj- PRO-5a also increased urinary sodium/creatinine ratio (56.5%). At 0.47 nmol/kg, Bj-PROs did not change renal function. All doses of Bj-PROs reduced blood pressure (Δ = −13 to −24mmHg). We conclude that Bj-PROs reduce blood pressure and improve renal functi |
URI: | http://www.repositorio.ufop.br/handle/123456789/9187 |
Link para o artigo: | https://link.springer.com/article/10.1007/s10989-017-9575-7 |
DOI: | https://doi.org/10.1007/s10989-017-9575-7 |
ISSN: | 1573-3904 |
Aparece nas coleções: | DECBI - Artigos publicados em periódicos |
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ARTIGO_BjPRO5a.pdf Restricted Access | 916,12 kB | Adobe PDF | Visualizar/Abrir |
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