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Title: LINE-1 and inflammatory gene methylation levels are early biomarkers of metabolic changes : association with adiposity.
Authors: Carraro, Júlia Cristina Cardoso
Mansego, Maria Luisa
Milagro, Fermín Ignacio
Chaves, Larissa Oliveira
Vidigal, Fernanda de Carvalho
Bressan, Josefina
Martinez, Alfredo
Keywords: Global DNA methylation
Healthy eating index
Metabolic syndrome
Issue Date: 2016
Citation: CARRARO, J. C. C. et al. LINE-1 and inflammatory gene methylation levels are early biomarkers of metabolic changes: association with adiposity. Biomarkers, v. 21, n. 7, p. 1-8, 2016. Disponível em: <>. Acesso em: 29 ago. 2017.
Abstract: We analyzed whether global and inflammatory genes methylation can be early predictors of metabolic changes and their associations with the diet, in a cross-sectional study (n¼40). Higher global methylation was associated to adiposity, insulin resistance, and lower quality of the diet. Methylation of IL-6, SERPINE1 and CRP genes was related to adiposity traits and macronutrients intake. SERPINE1 hypermethylation was also related to some metabolic alterations. CRP methylation was a better predictor of insulin resistance than CRP plasma concentrations. Global and inflammatory gene promoter hypermethylation can be good early biomarkers of adiposity and metabolic changes and are associated to the quality of the diet.
ISSN: 1752-0371
Appears in Collections:DENCS - Artigos publicados em periódicos

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