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Título: | Differential expression of iron metabolism proteins in diabetic and diabetic iron-supplemented rat liver. |
Autor(es): | Silva, Maísa Magalhães, Cíntia Lopes de Brito Oliveira, Riva de Paula Silva, Marcelo Eustáquio Pedrosa, Maria Lúcia |
Palavras-chave: | Carbonyl iron Streptozotocin Hepcidin Ferritin |
Data do documento: | 2012 |
Referência: | SILVA, M. et al. Differential expression of iron metabolism proteins in diabetic and diabetic iron-supplemented rat liver. Journal of Biochemical and Molecular Toxicology, v. 26, p. 123-129, 2012. Disponível em: <http://onlinelibrary.wiley.com/doi/10.1002/jbt.20418/epdf>. Acesso em: 20 de jul. 2017. |
Resumo: | Diabetes mellitus is associated with altered iron homeostasis that can potentially effect reactive oxygen species generation and contribute to diabetes-related complications. We investigated, by quantitative polymerase chain reaction, whether the expression of liver hepcidin, ferritin, and TfR-1 is altered in diabetes. Rats in the control (C) group received a standard diet; control iron (CI) group received a standard diet supplemented with iron; diabetic (D) group received an injection of streptozotocin; and diabetic iron (DI) group received streptozotocin and the diet with iron.Animals of theDgroup showed higher levels of serum iron, increased concentration of carbonyl protein, and a decrease in antioxidant status. Group D rats showed increased hepatic expression of Trf-1 compared to the other groups. Iron supplementation reversed this increase. Hepcidin mRNA was 81% higher in DI than in C and CI rats. The results suggest that diabetes, with or without excess iron, can cause perturbations in iron status, hepcidin and Trf-1 expression. |
URI: | http://www.repositorio.ufop.br/handle/123456789/8527 |
Link para o artigo: | http://onlinelibrary.wiley.com/doi/10.1002/jbt.20418/epdf |
DOI: | https://doi.org/10.1002/jbt.20418 |
ISSN: | 1099-0461 |
Aparece nas coleções: | DEBIO - Artigos publicados em periódicos |
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ARTIGO_DifferentialExpressionIron.pdf Restricted Access | 162,49 kB | Adobe PDF | Visualizar/Abrir |
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