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Título: | Computational identification and evolutionary relationships of the MicroRNA gene cluster miR-71/2 in protostomes. |
Autor(es): | Gomes, Matheus de Souza Donoghue, Mark T. A. Muniyappa, Mohan Kumar Pereira, Roberta Verciano Cota, Renata Guerra de Sá Spillane, Charles |
Data do documento: | 2013 |
Referência: | GOMES, M. de S. et al. Computational identification and evolutionary relationships of the MicroRNA gene cluster miR-71/2 in protostomes. Journal of Molecular Evolution, v. 76, p. 353-358, 2013. Disponível em: <https://link.springer.com/article/10.1007%2Fs00239-013-9563-2>. Acesso em: 23 fev. 2017. |
Resumo: | MicroRNAs (miRNAs) are small noncoding RNA molecules which are processed into *20–24 nt molecules that can regulate the gene expression posttranscriptionally. MiRNA gene clusters have been identified in a range of species, where in miRNAs are often processed from polycistronic transcripts. In this study, a computational approach is used to investigate the extent of evolutionary conservation of the miR-71/2 cluster in animals, and to identify novel miRNAs in the miRNA cluster miR-71/2. The miR-71/2 cluster, consisting of copies of the miR-71 and miR-2 (including miR-13) families, was found to be Protostome-specific. Although, this cluster is highly conserved across the Protostomia, the miR-2 family is completely absent from the Deuterostomia species, while miR-71 is absent from the Vertebrata and Urochordata. The evolutionary conservation and clustering propensity of the miR-71/2 family across the Protostomes could indicate the common functional roles across the member species of the Protostomia. |
URI: | http://www.repositorio.ufop.br/handle/123456789/8049 |
Link para o artigo: | https://link.springer.com/article/10.1007%2Fs00239-013-9563-2 |
DOI: | https://doi.org/10.1007/s00239-013-9563-2 |
ISSN: | 1432-1432 |
Aparece nas coleções: | DECBI - Artigos publicados em periódicos |
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ARTIGO_ComputationalIdentificationEvolutionary.pdf Restricted Access | 312,8 kB | Adobe PDF | Visualizar/Abrir |
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