Use este identificador para citar ou linkar para este item: http://www.repositorio.ufop.br/handle/123456789/7982
Título: 2,2’,4-Trihydroxybenzophenone : crystal structure, and anti-inflammatory and antioxidant activities.
Autor(es): Doriguetto, Antônio Carlos
Martins, Felipe Terra
Ellena, Javier
Salloum, Rogério
Santos, Marcelo Henrique dos
Moreira, Maria Eliza de Castro
Silva, Jose Mauricio Schneedorf Ferreira da
Nagem, Tanus Jorge
Data do documento: 2007
Referência: DORIGUETTO, A. C. et al. 2,2’,4-Trihydroxybenzophenone : crystal structure, and anti-inflammatory and antioxidant activities. Chemistry & Biodiversity, v. 4, p. 488-499, 2007. Disponível em: <http://onlinelibrary.wiley.com/doi/10.1002/cbdv.200790041/abstract>. Acesso em: 20 mai. 2017.
Resumo: The crystal structure of C 2,2’,4-trihydroxybenzophenoneD (¼(2,4-dihydroxyphenyl)(2-hydroxyphenyl) methanone; 1) was determined, and its molecular structure, along with intra- and intermolecular Hbonds, was analyzed. The anti-inflammatory potential of 1, evaluated by means of the rat-paw-edema assay, with carrageenan as inflammation stimulus, was found to be similar high as that of indomethacin. In contrast, benzophenone proper (2) was hardly active in this assay. Our results indicate that these antiinflammatory effects are related to the action of kinins and prostaglandins. The radical-scavenging properties of 1 towards DPPH were found to be similar as those of typical phenolics, but somewhat lower than that of ascorbic acid. The structure–activity relationship (SAR) of 1 is discussed.
URI: http://www.repositorio.ufop.br/handle/123456789/7982
Link para o editor: http://onlinelibrary.wiley.com/doi/10.1002/cbdv.200790041/abstract
ISSN: 16121880
Aparece nas coleções:DEQUI - Artigos publicados em periódicos

Arquivos associados a este item:
Arquivo Descrição TamanhoFormato 
ARTIGO_TrihydroxybenzopheneCrystalStructure.pdf348,36 kBAdobe PDFVisualizar/Abrir    Solictar uma cópia


Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.