Please use this identifier to cite or link to this item:
Title: Dietary açai modulates ROS production by neutrophils and gene expression of liver antioxidant enzymes in rats.
Authors: Guerra, Joyce Ferreira da Costa
Magalhães, Cíntia Lopes de Brito
Costa, Daniela Caldeira
Silva, Marcelo Eustáquio
Pedrosa, Maria Lúcia
Keywords: Antioxidant enzymes expression
Issue Date: 2011
Citation: GUERRA, J. F. da C. et al. Dietary açai modulates ROS production by neutrophils and gene expression of liver antioxidant enzymes in rats. Journal of Clinical Biochemistry and Nutrition, v. June, p. 1-7, 2011. Disponível em: <>. Acesso em: 19 fev. 2017.
Abstract: Açai (Euterpe oleracea Mart.) has recently emerged as a promising source of natural antioxidants. Because increased oxidative stress and impaired antioxidant defense mechanisms are important factors in the development of diabetic complications and many health claims have been reported for açai, the present study was undertaken to evaluate the possible protective effects of açai on the production of reactive oxygen species by neutrophils and on the liver antioxidant defense system in control and streptozotocin-induced diabetic rats. Diet supplementation with 2% açai was found to increase mRNA levels for gamma-glutamylcysteine synthetase and glutathione peroxidase in liver tissue and to decrease reactive oxygen species production by neutrophils. Compared to control animals, diabetic rats exhibited lower levels of mRNA coding for Zn-superoxide dismutase, glutathione peroxidase and gamma-glutamylcysteine synthetase and higher levels of reactive oxygen species production by neutrophils, thiobarbituric acid-reactive substances and carbonyl proteins in hepatic tissues. Although açai supplementation was not effective in restore gene expression of antioxidant enzymes in diabetic rats, it showed a protective effect, decreasing thiobarbituric acid-reactive substances levels and increasing reduced glutathione content in the liver. These findings suggest that açai can modulate reactive oxygen species production by neutrophils and that it has a significant favorable effect on the liver antioxidant defense system under fisiological conditions of oxidative stress and partially revert deleterious effects of diabetes in the liver.
ISSN:  1880-5086
Appears in Collections:DECBI - Artigos publicados em periódicos

Files in This Item:
File Description SizeFormat 
  Restricted Access
328,82 kBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.