Please use this identifier to cite or link to this item: http://www.repositorio.ufop.br/jspui/handle/123456789/7585
Title: Protein-energy malnutrition decreases immune response to Leishmania chagasi vaccine in BALB/c mice.
Authors: Malafaia, Guilherme
Serafim, Tiago Donatelli
Silva, Marcelo Eustáquio
Pedrosa, Maria Lúcia
Rezende, Simone Aparecida
Keywords: Nutritional repletion
Vaccination
Issue Date: 2009
Citation: MALAFAIA, G. et al. Protein-energy malnutrition decreases immune response to Leishmania chagasi vaccine in BALB/c mice. Parasite Immunology, v. 31, p. 41-49, 2009. Disponível em: <http://onlinelibrary.wiley.com/doi/10.1111/j.1365-3024.2008.01069.x/pdf>. Acesso em: 20 jan. 2017.
Abstract: Protein-energy malnutrition and visceral leishmaniasis are important problems of public health affecting millions of people worldwide. Vaccine efficacy depends on the ability of individuals to mount an appropriate immune response and may be inadequate in malnourished persons. In this study, we used a mouse model to verify the effect of combined protein, iron and zinc deficiency in the response to Leishmania chagasi antigen vaccine. BALB/c mice were fed with a low-protein (3% casein), iron- and zinc-deficient diet or control diet (14% casein and sufficient in zinc and iron). After malnutrition establishment, mice were vaccinated subcutaneously with L. chagasi Ag plus saponin. After vaccination, mice were nutritionally repleted and then all mice were challenged with L. chagasi promastigotes. Four weeks later, liver and spleen parasite load was evaluated. Our data show that vaccine caused a significant reduction in parasite load in spleen and liver from mice fed with control diet. However, splenic parasitism was increased in mice fed with deficient diet and this diet caused a reduction in splenocyte IFN-γ production in response to the vaccine in repleted mice. These data suggest that malnutrition may alter immune response to L. chagasi vaccine in BALB/c model of infection, even after nutritional repletion.
URI: http://www.repositorio.ufop.br/handle/123456789/7585
metadata.dc.identifier.uri2: https://onlinelibrary.wiley.com/doi/full/10.1111/j.1365-3024.2008.01069.x
metadata.dc.identifier.doi: https://doi.org/10.1111/j.1365-3024.2008.01069.x
ISSN: 1365-3024
Appears in Collections:DEFAR - Artigos publicados em periódicos

Files in This Item:
File Description SizeFormat 
ARTIGO_ProteinEnergyMalnutrition.pdf
  Restricted Access
227,78 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.