Please use this identifier to cite or link to this item:
Title: Trypanosoma cruzi high infectivity in vitro is related to cardiac lesions during long-term infection in beagle dogs.
Authors: Guedes, Paulo Marcos da Matta
Veloso, Vanja Maria
Caliari, Marcelo Vidigal
Carneiro, Cláudia Martins
Souza, Sheler Martins de
Lana, Marta de
Chiari, Egler
Bahia, Maria Terezinha
Galvão, Lúcia Maria da Cunha
Keywords: Chagas disease
Issue Date: 2007
Citation: GUEDES, P. M. da M. et al. Trypanosoma cruzi high infectivity in vitro is related to cardiac lesions during long-term infection in beagle dogs. Memórias do Instituto Oswaldo Cruz, v. 102, p.141-147, 2007. Disponível em: <>. Acesso em: 10 jan. 2017.
Abstract: Trypanosoma cruzi is a hemoflagelate parasite associated with heart dysfunctions causing serious problems in Central and South America. Beagle dogs develop the symptoms of Chagas disease in humans, and could be an important experimental model for better understanding the immunopathogenic mechanisms involved in the chagasic infection. In the present study we investigated the relation among biological factors inherent to the parasite (trypomastigote polymorphism and in vitro infectivity) and immunoglobulin production, inflammation, and fibrosis in the heart of Beagle dogs infected with either T. cruzi Y or Berenice-78 strains. In vitro infectivity of Vero cells as well as the extension of cardiac lesions in infected Beagle was higher for Y strain when compared to Berenice-78 strain. These data suggested that in vitro infectivity assays may correlate with pathogenicity in vivo. In fact, animals infected with Y strain, which shows prevalence of slender forms and high infectivity in vitro, presented cardiomegaly, inflammation, and fibrosis in heart area. Concerning the immunoglobulin production, no statistically significant difference was observed for IgA, IgM or IgG levels among T. cruzi infected animals. However, IgA together IgM levels have shown to be a good marker for the acute phase of Chagas disease.
ISSN: 0074-0276
metadata.dc.rights.license: Todo o conteúdo do periódico Memórias do Instituto Oswaldo Cruz, exceto onde identificado, está sob uma licença Creative Commons que permite copiar, distribuir e transmitir o trabalho em qualquer suporte ou formato desde que sejam citados o autor e o licenciante. Não permite o uso para fins comerciais. Fonte: Memórias do Instituto Oswaldo Cruz <>. Acesso em: 19 ago. 2019.
Appears in Collections:DEFAR - Artigos publicados em periódicos

Files in This Item:
File Description SizeFormat 
ARTIGO_TrypanosomaCruziInfectivity.pdf269,05 kBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.