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dc.contributor.authorAbreu, Alessandra Rezende Ribeiro de-
dc.contributor.authorSantos, Laura Gomes Batista Tavares-
dc.contributor.authorSouza, Aline Maria Arlindo de-
dc.contributor.authorSilva, L. G. da-
dc.contributor.authorChianca Júnior, Deoclécio Alves-
dc.contributor.authorMenezes, Rodrigo Cunha Alvim de-
dc.identifier.citationABREU, A. R. R. de. et al. Amygdalar neuronal activity mediates the cardiovascular responses evoked from the dorsolateral periaqueductal gray in conscious rats. Neuroscience, v. 284, p. 737-750, 2015. Disponível em: <>. Acesso em: 15 out. 2015.pt_BR
dc.description.abstractThere is ample evidence that both lateral/ dorsolateral periaqueductal gray (l/dlPAG) and basolateral amygdala (BLA) are essential for the regulation of the autonomic responses evoked during innate reactions to threatening stimuli. However, it is not well established to what extent the BLA regulates the upstream functional connection from the l/dlPAG. Here we evaluated the role of the BLA and its glutamatergic receptors in the cardiovascular responses induced by l/dlPAG stimulation in rats. We examined the influence of acute inhibition of the BLA, unilaterally, by injecting muscimol on the cardiovascular responses evoked by the injection of N-methyl D-aspartate (NMDA) into the l/dlPAG. We also evaluated the role of BLA ionotropic glutamate receptors in these responses by injecting antagonists of NMDA and AMPA/kainate receptor subtypes into the BLA. Our results show that the microinjection of NMDA in the BLA increased the mean arterial pressure (MAP) and heart rate (HR). Injection of NMDA into the l/dlPAG caused similar increases in these variables, which was prevented by the prior injection of muscimol, a GABAA agonist, into the BLA. Moreover, injection of glutamatergic antagonists (2-amino-5-phosphonopentanoate (AP5) and 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX)) into the BLA reduced the increase in MAP and HR induced by l/dlPAG activation. Finally, the inhibition of the central amygdala neurons failed to reduce the cardiovascular changes induced by l/dlPAG activation. These results indicate that physiological responses elicited by l/dlPAG activation require the neuronal activity in the BLA. This ascending excitatory pathway from the l/dlPAG to the BLA might ensure the expression of the autonomic component of the defense reactionpt_BR
dc.subjectPeriaqueductal graypt_BR
dc.subjectBasolateral amygdalapt_BR
dc.subjectGlutamatergic receptorspt_BR
dc.subjectDefense reactionpt_BR
dc.titleAmygdalar neuronal activity mediates the cardiovascular responses evoked from the dorsolateral periaqueductal gray in conscious rats.pt_BR
dc.typeArtigo publicado em periodicopt_BR
dc.rights.licenseO periódico Neuroscience concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3732991325626.pt_BR
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