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Título: | Coxsackievirus B5 induced apoptosis of HeLa cells : effects on p53 and SUMO. |
Autor(es): | Gomes, Rogério Cota, Renata Guerra de Sá Arruda, Eurico |
Palavras-chave: | Coxsackievirus B5 Apoptosis |
Data do documento: | 2010 |
Referência: | GOMES, R.; SÁ, R. G.; ARRUDA, E. Coxsackievirus B5 induced apoptosis of HeLa cells: effects on p53 and SUMO. Journal of Virology, v. 396, p. 256-263, 2010. Disponível em: <http://www.sciencedirect.com/science/article/pii/S004268220900614X>. Acesso em: 08 nov. 2014. |
Resumo: | Coxsackievirus B5 (CVB5), a human enterovirus of the family Picornaviridae, is a frequent cause of acute and chronic human diseases. The pathogenesis of enteroviral infections is not completely understood, and the fate of the CVB5-infected cell has a pivotal role in this process. We have investigated the CVB5-induced apoptosis of HeLa cells and found that it happens by the intrinsic pathway by a mechanism dependent on the ubiquitin–proteasome system, associated with nuclear aggregation of p53. Striking redistribution of both SUMO and UBC9 was noted at 4 h post-infection, simultaneously with a reduction in the levels of the ubiquitin-ligase HDM2. Taken together, these results suggest that CVB5 infection of HeLa cells elicit the intrinsic pathway of apoptosis by MDM2 degradation and p53 activation, destabilizing protein sumoylation, by a mechanism that is dependent on a functional ubiquitin–proteasome system. |
URI: | http://www.repositorio.ufop.br/handle/123456789/4932 |
DOI: | https://doi.org/10.1016/j.virol.2009.10.005 |
ISSN: | 0042-6822 |
Licença: | O periódico Virology concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3547120273893. |
Aparece nas coleções: | DECBI - Artigos publicados em periódicos |
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ARTIGO_CoxsackievirusB5Induced.pdf | 2,25 MB | Adobe PDF | Visualizar/Abrir |
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