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Title: Açaí (Euterpe oleracea Mart.) modulates oxidative stress resistance in Caenorhabditis elegans by direct and indirect mechanisms.
Authors: Bonomo, Larissa de Freitas
Silva, David Nunes
Boasquivis, Patrícia Ferreira
Paiva, Franciny Aparecida
Guerra, Joyce Ferreira da Costa
Martins, Talita Alves Faria
Torres, Álvaro Gustavo de Jesus
Paula, Igor Thadeu Borges Raposo de
Caneschi, Washington Luiz
Jacolot, Philippe
Grossin, Nicolas
Tessier, Frederic J.
Boulanger, Eric
Silva, Marcelo Eustáquio
Pedrosa, Maria Lúcia
Oliveira, Riva de Paula
Issue Date: 2014
Citation: BONOMO, L. de F. et al. Açaí (Euterpe oleracea Mart.) modulates oxidative stress resistance in Caenorhabditis elegans by direct and indirect mechanisms. Plos One, v. 9, p. e89933, 2014. Disponível em: <>. Acesso em: 15 out. 2014.
Abstract: Açaí (Euterpe oleracea Mart.) has recently emerged as a promising source of natural antioxidants. Despite its claimed pharmacological and nutraceutical value, studies regarding the effects of açaí in vivo are limited. In this study, we use the Caenorhabditis elegans model to evaluate the in vivo antioxidant properties of açaí on an organismal level and to examine its mechanism of action. Supplementation with ac¸aı´ aqueous extract (AAE) increased both oxidative and osmotic stress resistance independently of any effect on reproduction and development. AAE suppressed bacterial growth, but this antimicrobial property did not influence stress resistance. AAE-increased stress resistance was correlated with reduced ROS production, the prevention of sulfhydryl (SH) level reduction and gcs-1 activation under oxidative stress conditions. Our mechanistic studies indicated that AAE promotes oxidative stress resistance by acting through DAF-16 and the osmotic stress response pathway OSR-1/UNC-43/SEK-1. Finally, AAE increased polyglutamine protein aggregation and decreased proteasome activity. Our findings suggest that natural compounds available in AAE can improve the antioxidant status of a whole organism under certain conditions by direct and indirect mechanisms.
ISSN: 1932-6203
metadata.dc.rights.license: Os trabalhos publicados na Plos one estão sob Licença Creative Commons que permite copiar, distribuir e transmitir o trabalho, desde que sejam citados o autor e licenciante. Não permite o uso para fins comerciais nem a adaptação. Fonte: Plos one <>. Acesso em: 03 jan. 2017.
Appears in Collections:DEBIO - Artigos publicados em periódicos

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