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Title: Increased type 1 chemokine expression in experimental Chagas disease correlates with cardiac pathology in Beagle dogs.
Authors: Guedes, Paulo Marcos da Matta
Veloso, Vanja Maria
Silva, André Talvani Pedrosa da
Diniz, Lívia de Figueiredo
Caldas, Ivo Santana
Matta, Maria Adelaide do Valle
Silva, Juliana Santiago
Chiari, Egler
Galvão, Lúcia Maria da Cunha
Silva, João Santana da
Bahia, Maria Terezinha
Keywords: Chemokines
Dog model
Trypanosoma cruzi
Chagas cardiopathy
Issue Date: 2010
Citation: GUEDES, P. M. M. et al. Increased type 1 chemokine expression in experimental Chagas disease correlates with cardiac pathology in Beagle dogs. Veterinary Immunology and Immunopathology, v. 138, p. 106-113, 2010. Disponível em: <>. Acesso em: 08 nov. 2014.
Abstract: Chemokines and chemokine receptors interaction have presented important role in leukocyte migration to specific immune reaction sites. Recently, it has been reported that chemokine receptors CXC (CXCR3) and CC (CCR5) were preferentially expressed on Th1 cells while CCR3 and CCR4 were preferentially expressed on Th2 cells. This study evaluated the mRNA expression of type 1 and type 2 chemokine and chemokine receptors in the cardiac tissue of Beagle dogs infected with distinct genetic groups of Trypanosoma cruzi (Y, Berenice- 78 and ABC strains) during acute and chronic phases. To analyze the correlation between chemokine and chemokine receptors expression and the development of heart pathology, the chronic infected animals were divided into groups, according to the parasite strain and based on the degree of heart damage: cardiac and indeterminate form of Chagas disease. Our results indicated that cardiac type1/2 chemokines and their receptors were partially dependent on the genetic diversity of parasites as well as the polarization of clinical forms. Also, dogs presenting cardiac form showed lower heart tissue mRNA expression of CCL24 (type 2) and higher expression of CCL5, CCL4 and CXCR3 (type 1) when compared with those with indeterminate form of disease. Together, these data reinforce a close-relation between T. cruzi genetic population and the host specific type 1 immune response and, for the first time, we show the distribution of type 1/2 chemokines associated with the development of cardiac pathology using dogs, a well similar model to study human Chagas disease.
ISSN: 0165-2427
metadata.dc.rights.license: O periódico Veterinary Immunology and Immunopathology concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3544871342043.
Appears in Collections:DECBI - Artigos publicados em periódicos

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