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Título: The hypocholesterolemic activity of açaí (Euterpe oleracea Mart.) is mediated by the enhanced expression of the ATP-binding cassette, subfamily G transporters 5 and 8 and low-density lipoprotein receptor genes in the rat.
Autor(es): Souza, Melina Oliveira de
Silva, Lorena Souza e
Magalhães, Cíntia Lopes de Brito
Figueiredo, Bianca Barros de
Costa, Daniela Caldeira
Silva, Marcelo Eustáquio
Pedrosa, Maria Lúcia
Palavras-chave: Euterpe
Hypercholesterolemia
Açaí
Cholesterol
Data do documento: 2012
Referência: SOUZA, M. O. et al. The hypocholesterolemic activity of açaí (Euterpe oleracea Mart.) is mediated by the enhanced expression of the ATP-binding cassette, subfamily G transporters 5 and 8 and low-density lipoprotein receptor genes in the rat. Nutrition Research, v. 32, p. 976-984, 2012. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0271531712002102>. Acesso em: 08 nov. 2014.
Resumo: Previous studies have demonstrated that the ingestion of açaí pulp can improve serum lipid profile in various animal models; therefore, we hypothesized that açaí pulp (Euterpe oleracea Mart.) may modulate the expression of the genes involved in cholesterol homeostasis in the liver and increase fecal excretion, thus reducing serum cholesterol. To test this hypothesis, we analyzed the expression of 7α-hydroxylase and ATP-binding cassette, subfamily G transporters (ABCG5 and ABCG8), which are genes involved with the secretion of cholesterol in the rat. We also evaluated the expression of sterol regulatory element–binding protein 2, 3-hydroxy-3-methylglutaryl CoA reductase, low-density lipoprotein receptor (LDL-R), and apolipoprotein B100, which are involved in cholesterol biosynthesis. Female Fischer rats were divided into 4 groups: the C group, which was fed a standard AIN-93 M diet; the CA group, which was fed a standard diet supplemented with 2% açaí pulp; the H group, which was fed a hypercholesterolemic diet (25% soy oil and 1% cholesterol); and the HA group, which was fed a hypercholesterolemic diet supplemented with 2% açaí pulp. At the end of the experimental period, the rats were euthanized, and their blood and livers were collected. The HA group exhibited a significant decrease in serum total cholesterol, low-density lipoprotein cholesterol, and atherogenic index and also had increased high-density lipoprotein cholesterol and cholesterol excretion in feces compared with the H group. In addition, the expression of the LDL-R, ABCG5, and ABCG8 genes was significantly increased by the presence of açaí pulp. These results suggest that açaí pulp promotes a hypocholesterolemic effect in a rat model of dietary-induced hypercholesterolemia through an increase in the expression of ATP-binding cassette, subfamily G transporters and LDL-R genes.
URI: http://www.repositorio.ufop.br/handle/123456789/4187
ISSN: 02715317
Licença: O Periódico Nutrition Research concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3520371116208.
Aparece nas coleções:DECBI - Artigos publicados em periódicos

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