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Title: Genetic composition of a Brazilian population : the footprint of the Gold Cycle.
Authors: Queiroz, Erica Maria de
Santos, A. M.
Castro, Ieso de Miranda
Coelho, George Luiz Lins Machado
Mendes, Ana Paula Carlos Cândido
Leite, Tailce Moura
Pereira, Rinaldo Wellerson
Freitas, Renata Nascimento de
Keywords: Ancestry-informative markers
Genetic ancestry
Skin color
Brazilian population
Issue Date: 2013
Citation: QUEIROZ, E. M. de. el al. Genetic composition of a Brazilian population : the footprint of the Gold Cycle. Genetics and Molecular Research, v. 12, n. 4, p. 5124-5133, 2013. Disponível em: <>. Acesso em: 2 set. 2014.
Abstract: Ancestry-informative markers (AIMs) are powerful tools for inferring the genetic composition of admixed populations. In this study, we determined the genetic ancestry of the Ouro Preto (Brazil) population and evaluated the association between ancestry and self-reported skin color. The genetic ancestry of 189 children and adolescents was estimated by genotyping 15 AIMs. The estimate of population admixture was determined using the Bayesian Markov Chain Monte Carlo (MCMC) method implemented in two different programs (STRUCTURE and ADMIXMAP). Volunteers self-reported their skin colors. The European ancestry contribution ranged from 0.503 to 0.539, the African contribution ranged from 0.333 to 0.425, and the Amerindian component ranged from 0.04 to 0.164. The relative contributions of African (P < 0.016) and European (P < 0.011) ancestry differed significantly among skin color groups, except between black and dark-brown groups. The population of Ouro Preto has a higher contribution of African ancestry compared to the mean for the southeast region of Brazil. Therefore, extrapolating the African ancestry contribution for southeastern Brazil to the Ouro Preto population would underestimate the actual value for this city. We also showed that self-reported skin color could be appropriate for describing the genetic structure of this particular population.
ISSN: 1676-5680
metadata.dc.rights.license: A revista Genetics and Molecular Biology permite que o Repositório Institucional da Universidade Federal de Ouro Preto (UFOP) deposite uma cópia eletrônica dos artigos publicados por esse periódico  em que ao menos um dos autores faça parte da comunidade cientifica da UFOP. Fonte: Licença concedida mediante preenchimento de formulário no dia 19 nov. 2013.
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