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http://www.repositorio.ufop.br/jspui/handle/123456789/16424
Título: | Ayahuasca, a psychedelic beverage, modulates neuroplasticity induced by ethanol in mice. |
Autor(es): | Almeida, Carolina Aparecida de Faria Pereira Júnior, Antônio Alves Rangel, Jéssica Gonçalves Pereira, Bruna Pinheiro Costa, Karla Cristinne Mancini Bruno, Vitor Silveira, Gabriela Oliveira Ceron, Carla Speroni Yonamine, Mauricio Camarini, Rosana Garcia, Raphael Caio Tamborelli Marcourakis, Tania Torres, Larissa Helena |
Palavras-chave: | N,N-dimethyltryptamine Withdrawal Ethanol Behavioral sensitization β-carboline |
Data do documento: | 2022 |
Referência: | ALMEIDA, C. A. F. et al. Ayahuasca, a psychedelic beverage, modulates neuroplasticity induced by ethanol in mice. Behavioural Brain Research, v. 416, artigo 113546, jan. 2022. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0166432821004344>. Acesso em: 11 out. 2022. |
Resumo: | Alcohol use disorder needs more effective treatments because relapse rates remain high. Psychedelics, such as ayahuasca, have been used to treat substance use disorders. Our study aimed to evaluate the effects of ayahuasca on ethanol-induced behavioral sensitization (EIBS). Swiss mice received 2.2 g/kg ethanol or saline IP injections every other day across nine days (D1, D3, D5, D7, and D9), and locomotor activity was evaluated 10 min after each injection. Then, animals were treated daily with ayahuasca (corresponding to 1.76 mg/kg of N,N- dimethyltryptamine, DMT) or water by oral gavage for eight consecutive days. On the seventh day, mice were evaluated in the elevated plus maze. Then, mice were challenged with a single dose of ethanol to measure their locomotor activity. Dopamine receptors, serotonin receptors, dynorphin, and prodynorphin levels were quanti- fied in the striatum and hippocampus by blot analysis. Repeated ethanol administration resulted in EIBS. However, those animals treated with ayahuasca had an attenuated EIBS. Moreover, ayahuasca reduced the anxiogenic response to ethanol withdrawal and prevented the ethanol-induced changes on 5-HT1a receptor and prodynorphin levels in the hippocampus and reduced ethanol effects in the dynorphin/prodynorphin ratio levels in the striatum. These results suggest a potential application of ayahuasca to modulate the neuroplastic changes induced by ethanol. |
URI: | http://www.repositorio.ufop.br/jspui/handle/123456789/16424 |
Link para o artigo: | https://www.sciencedirect.com/science/article/pii/S0166432821004344 |
DOI: | https://doi.org/10.1016/j.bbr.2021.113546 |
ISSN: | 0166-4328 |
Aparece nas coleções: | DECBI - Artigos publicados em periódicos |
Arquivos associados a este item:
Arquivo | Descrição | Tamanho | Formato | |
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ARTIGO_AyahuascaPsychedelicBeverage.pdf Restricted Access | 2,31 MB | Adobe PDF | Visualizar/Abrir |
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