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Título: | Hippocampal function is impaired by a short-term high-fat diet in mice : increased blood–brain barrier permeability and neuroinflammation as triggering events. |
Autor(es): | Paula, Gabriela Cristina de Brunetta, Henver Simionato Engel, Daiane Fátima Gaspar, Joana Margarida Navalho Velloso, Licio Augusto Engblom, David Oliveira, Jade de Bem, Andreza Fabro de |
Palavras-chave: | Cognition Memory Depression Mitochondria Bioenergetics |
Data do documento: | 2021 |
Referência: | PAULA, G. C. de. et al. Hippocampal function is impaired by a short-term high-fat diet in mice: increased blood–brain barrier permeability and neuroinflammation as triggering events. Frontiers in Neuroscience, v. 15, nov. 2021. Disponível em: <https://www.frontiersin.org/articles/10.3389/fnins.2021.734158/full>. Acesso em: 11 out. 2022. |
Resumo: | Worldwide, and especially in Western civilizations, most of the staple diets contain high amounts of fat and refined carbohydrates, leading to an increasing number of obese individuals. In addition to inducing metabolic disorders, energy dense food intake has been suggested to impair brain functions such as cognition and mood control. Here we demonstrate an impaired memory function already 3 days after the start of a high-fat diet (HFD) exposure, and depressive-like behavior, in the tail suspension test, after 5 days. These changes were followed by reduced synaptic density, changes in mitochondrial function and astrocyte activation in the hippocampus. Preceding or coinciding with the behavioral changes, we found an induction of the proinflammatory cytokines TNF-α and IL-6 and an increased permeability of the blood–brain barrier (BBB), in the hippocampus. Finally, in mice treated with a TNF-α inhibitor, the behavioral and BBB alterations caused by HFD-feeding were mitigated suggesting that inflammatory signaling was critical for the changes. In summary, our findings suggest that HFD rapidly triggers hippocampal dysfunction associated with BBB disruption and neuroinflammation, promoting a progressive breakdown of synaptic and metabolic function. In addition to elucidating the link between diet and cognitive function, our results might be relevant for the comprehension of the neurodegenerative process. |
URI: | http://www.repositorio.ufop.br/jspui/handle/123456789/15938 |
DOI: | https://doi.org/10.3389/fnins.2021.734158 |
ISSN: | 1662-453X |
Licença: | This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Fonte: o PDF do artigo. |
Aparece nas coleções: | DEACL - Artigos publicados em periódicos |
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ARTIGO_HippocampalFunctionImpaired.pdf | 4,54 MB | Adobe PDF | Visualizar/Abrir |
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