Please use this identifier to cite or link to this item: http://www.repositorio.ufop.br/jspui/handle/123456789/14248
Title: Antitumor activity of Pd(II) complexes with N,S or O,S coordination modes of acylthiourea ligands.
Authors: Stevens, Ana María Plutín
Ramos Cairo, Raúl
Mocelo, Raúl
Alvarez Hernández, Anislay
Castellano, Eduardo Ernesto
Cominetti, Márcia Regina
Oliveira, Katia Mara de
Oliveira, Tamires Donizeth de
Silva, Thales E. M.
Oliveira, Rodrigo Corrêa de
Batista, Alzir Azevedo
Keywords: Crystal structure
Cytotoxicity
Issue Date: 2020
Citation: STEVENS, A. M. P. et al. Antitumor activity of Pd(II) complexes with N,S or O,S coordination modes of acylthiourea ligands. Polyhedron, v. 184, artigo 114543, 2020. Disponível em: <https://www.sciencedirect.com/science/article/abs/pii/S027753872030200X?via%3Dihub>. Acesso em: 10 jun. 2021.
Abstract: Seven new complexes (1–7) of Pd(II) with N-alkyl- and N,N-dialkyl-N0 -acylthioureas were prepared and characterized by elemental analysis and spectroscopic techniques. The crystal structures of the coordination compounds [PdCl(PPh3)(5-cloropiridyl-N0 -benzoylthioureato-k2 N,S)] (2), cis-[Pd(PPh3)2 (N-morpholyn-N0 -benzoylthioureato-k2 O,S)]PF6 (4) and cis-[Pd(PPh3)2(N,N-diphenyl-N0 -thiophenylth ioureato-k2 O,S)]PF6 (7) were determined by X-ray crystallography. The present study reports on an inter esting contribution on the chemistry of Pd(II)/acylthiourea complexes, where the use of monosubstituted acylthiourea conducts to formation of neutral complexes with general formula [Pd(Cl)(PPh3) (acylthiourea)], with a N,S-coordination mode. On the other hand, cationic complexes with formula [Pd (PPh3)2(acylthiourea)]+ , with O,S bidentately coordinated to the metal, are obtained by using a disubsti tuted acylthiourea derivative. The antitumor activity of the N-alkyl- and N,N-dialkyl-N0 -acylthiourea ligands and their palladium (II) complexes with synthesized triphenylphosphine were evaluated against the growth of the DU-145 tumor cells (prostate cancer cells), (MDA-MB-231 (breast cancer cells), L929 (healthy mouse cells). The ligands are not cytotoxic, but the complexes showed good cytotoxicity against the tumor cells tested in this work, and were even better, when compared to the IC50 reported for the cis platin. The complexes showed better activity results in MDA-MB-231 tumor cells, than for the DU-145 tumor cells. Complexes 1 and 6 showed high cytotoxic activity at low micromolar concentrations (IC50 = 1.93 ± 0.45, 0.62 ± 0.08 lM) against MDA-MB-231 (human breast cancer cells). This result indicated that the binding of the ligands to the metal center increases their antitumor activity.
URI: http://www.repositorio.ufop.br/jspui/handle/123456789/14248
metadata.dc.identifier.uri2: https://www.sciencedirect.com/science/article/abs/pii/S027753872030200X?via%3Dihub
metadata.dc.identifier.doi: https://doi.org/10.1016/j.poly.2020.114543
ISSN: 0277-5387
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