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Title: Trypanosoma cruzi : desferrioxamine decreases mortality and parasitemia in infected mice through a trypanostatic effect.
Authors: Arantes, Jerusa Marilda
Francisco, Amanda Fortes
Vieira, Paula Melo de Abreu
Silva, Maísa
Araújo, Márcio Sobreira Silva
Carvalho, Andréa Teixeira de
Pedrosa, Maria Lúcia
Carneiro, Cláudia Martins
Tafuri, Washington Luiz
Martins Filho, Olindo Assis
Santos, Silvana Maria Elói
Keywords: Trypanosoma cruzi
Etiological treatment
Experimental infection
Trypanostatic effect
Issue Date: 2011
Citation: ARANTES, J. M. et al. Trypanosoma cruzi : desferrioxamine decreases mortality and parasitemia in infected mice through a trypanostatic effect. Experimental Parasitology, v. 128, n. 4, p. 401-408, ago. 2011. Disponível em: <>. Acesso em: 12 set. 2012.
Abstract: Desferrioxamine (DFO) is a potent iron chelator that is also known to modulate inflammation and act as an efficient antioxidant under normal conditions and under oxidative stress. Many in vitro and in vivo studies have shown the efficacy of DFO in the treatment of viral, bacterial and protozoan infections. DFO is known to reduce the intensity of Trypanosoma cruzi infections in mice even during a course of therapy that is not effective in maintaining anaemia or low iron levels. To further clarify these findings, we investigated the action of DFO on mouse T. cruzi infection outcomes and the direct impact of DFO on parasites. Infected animals treated with DFO (5 mg/animal/day) for 35 days, beginning 14 days prior to infection, presented lower parasitemia and lower cumulative mortality rate. No significant effect was observed on iron metabolism markers, erythrograms, leukograms or lymphocyte subsets. In the rapid method for testing in vivo T. cruzi susceptibility, DFO also induced lower parasitemia. In regard to its direct impact on parasites, DFO slightly inhibited the growth of amastigotes and trypomastigotes in fibroblast culture. Trypan blue staining showed no effects of DFO on parasite viability, and only minor apoptosis in trypomastigotes was observed. Nevertheless, a clear decrease in parasite mobility was detected. In conclusion, the beneficial actions of DFO on mice T. cruzi infection seem to be independent of host iron metabolism and free of significant haematological side effects. Through direct action on the parasite, DFO has more effective trypanostatic than trypanocidal properties.
ISSN: 00144894
metadata.dc.rights.license: O periódico Experimental Parasitology concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3280851340833.
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