Please use this identifier to cite or link to this item: http://www.repositorio.ufop.br/jspui/handle/123456789/12184
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dc.contributor.authorMilagre, Matheus Marques-
dc.contributor.authorBranquinho, Renata Tupinambá-
dc.contributor.authorGonçalves, Maíra Fonseca-
dc.contributor.authorAssis, Gabriela Maíra Pereira de-
dc.contributor.authorOliveira, Maykon Tavares de-
dc.contributor.authorReis, Levi Eduardo Soares-
dc.contributor.authorGuimarães, Dênia Antunes Saúde-
dc.contributor.authorLana, Marta de-
dc.date.accessioned2020-05-12T14:44:30Z-
dc.date.available2020-05-12T14:44:30Z-
dc.date.issued2020-
dc.identifier.citationMILAGRE, M. M. et al. Activity of the sesquiterpene lactone goyazensolide against Trypanosoma cruzi in vitro and in vivo. Parasitology, v. 147, n. 1, p. 108-119, jan. 2020. Disponível em: <https://www.cambridge.org/core/journals/parasitology/article/activity-of-the-sesquiterpene-lactone-goyazensolide-against-trypanosoma-cruzi-in-vitro-and-in-vivo/3B0DB1C28842399A17939AE161EA131C>. Acesso em: 10 fev. 2020.pt_BR
dc.identifier.issn1469-8161-
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/12184-
dc.description.abstractBackground: The current drugs for Chagas disease treatment present several limitations Methods: The sesquiterpene lactone goyazensolide (GZL) was evaluated regarding to cytotoxicity and trypanocidal activity against amastigotes, selectivity index (SI) in vitro, acute toxicity and anti-Trypanosoma cruzi activity in vivo. Results: The in vitro cytotoxicity in H9c2 cells was observed at doses >250 ng mL−1 of GZL and the SI were of 52.82 and 4.85 (24 h) and of 915.00 and 41.00 (48 h) for GZL and BZ, respectively. Nephrotoxicity and hepatotoxicity were not verified. Treatment with GZL of mice infected with CL strain led to a significant decrease of parasitaemia and total survival at doses of 1 and 3 mg kg−1 day−1 by oral and IV, respectively. This last group cured 12.5% of the animals (negativation of HC, PCR, qPCR and ELISA). Animals infected with Y strain showed significant decrease of parasitaemia and higher negativation in all parasitological tests in comparison to BZ and control groups, but were ELISA reactive, as well as the BZ group, but mice treated with 5.0 mg kg−1 day−1 by oral were negative in parasitological tests and survived. Conclusion: GZL was more active against T. cruzi than benznidazole in vitro and presented important therapeutic activity in vivo in both T. cruzi strains.pt_BR
dc.language.isoen_USpt_BR
dc.rightsrestritopt_BR
dc.subjectToxicitypt_BR
dc.subjectTreatmentpt_BR
dc.titleActivity of the sesquiterpene lactone goyazensolide against Trypanosoma cruzi in vitro and in vivo.pt_BR
dc.typeArtigo publicado em periodicopt_BR
dc.identifier.uri2https://www.cambridge.org/core/journals/parasitology/article/activity-of-the-sesquiterpene-lactone-goyazensolide-against-trypanosoma-cruzi-in-vitro-and-in-vivo/3B0DB1C28842399A17939AE161EA131Cpt_BR
dc.identifier.doihttps://doi.org/10.1017/S0031182019001276pt_BR
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