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Title: Mayaro virus induction of oxidative stress is associated with liver pathology in a non-lethal mouse model.
Authors: Caetano, Camila Carla da Silva
Camini, Fernanda Caetano
Almeida, Letícia Trindade
Ferraz, Ariane Coelho
Silva, Tales Fernando da
Lima, Rafaela Lameira Souza
Carvalho, Mayara Medeiros de Freitas
Castro, Thalles de Freitas
Carneiro, Cláudia Martins
Silva, Breno de Mello
Silva, Silvana de Queiroz
Magalhães, José Carlos de
Magalhães, Cíntia Lopes de Brito
Issue Date: 2019
Citation: CAETANO, C. C. S. et al. Mayaro virus induction of oxidative stress is associated with liver pathology in a non-lethal mouse model. Scientific Reports, v. 9, p. 15289, out. 2019. Disponível em: <>. Acesso em: 10 fev. 2020.
Abstract: Mayaro virus (MAYV) causes Mayaro fever in humans, a self-limiting acute disease, with persistent arthralgia and arthritis. Although MAYV has a remerging potential, its pathogenic mechanisms remain unclear. Here, we characterized a model of MAYV infection in 3–4-week BALB/c mice. We investigated whether the liver acts as a site of viral replication and if the infection could cause histopathological alterations and an imbalance in redox homeostasis, culminating with oxidative stress. MAYV-infected mice revealed lower weight gain; however, the disease was self-resolving. High virus titre, neutralizing antibodies, and increased levels of aspartate and alanine aminotransferases were detected in the serum. Infectious viral particles were recovered in the liver of infected animals and the histological examination of liver tissues revealed significant increase in the inflammatory infiltrate. MAYV induced significant oxidative stress in the liver of infected animals, as well as a deregulation of enzymatic antioxidant components. Collectively, this is the first study to report that oxidative stress occurs in MAYV infection in vivo, and that it may be crucial in virus pathogenesis. Future studies are warranted to address the alternative therapeutic strategies for Mayaro fever, such as those based on antioxidant compounds.
ISSN: 2045-2322
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